Sepsis and Acute Lung Injury

  • G. R. Bernard
  • E. Holden
  • J. W. Christman
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 19)


Sepsis syndrome is associated with diffuse microvascular injury (predominantly lung injury) which appears to be related to a wide variety of physiologically active and tissue destructive mediators. The exact cause and effect relationship between mediators and pathophysiology is becoming increasingly better understood but much remains to be elucidated. Even in those situations where biochemical mechanisms have been well worked out in animal models, it remains to be seen whether or not the findings can be transferred to humans with sepsis. The tremendous homogeneity of the sepsis syndrome population make clinical studies of this group difficult and meaning of clinical findings subject to interpretation. Increasingly, however, the availability of high quality assays and pharmacologic interventions has placed this type of research on more firm footing. In this chapter, the clinical implications of the release of bioactive lipids and free radicals of oxygen will be explored in the light of the available clinical data just now becoming available.


Acute Lung Injury Idiopathic Pulmonary Fibrosis Adult Respiratory Distress Syndrome Bioactive Lipid Sepsis Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • G. R. Bernard
  • E. Holden
  • J. W. Christman

There are no affiliations available

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