Facing the Pancreatic Dilemma pp 217-225 | Cite as
The Role of Islets in Experimental Pancreatic Cancer
Abstract
Pancreatic exocrine cancer induced in Syrian hamsters by N-nitroso-bis(2-oxo-propyl)amine (BOP) and related compounds resembles the human disease morphologically, biologically, clinically, molecular biologically, and to some extent antigenitically [1–3]. Histological, immunohistochemical, and electron microscopical studies have shown that ductal and ductular cells are the progenitor cells of tumors [1]. Most affected are the peri- and intrainsular ductular cells [1], the proliferation of which is often the first histological finding [4]. The initial proliferation and malignant changes in the peri-insular and intrainsular ductules, with subsequent destruction of the affected islets, presented a mystery in terms of mechanistic events. The following observations were the basis for our hypothesis on the role of islets in pancreatic tumor induction.
Keywords
Pancreatic Cancer Islet Cell Submandibular Gland Islet Transplantation Syrian HamsterPreview
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References
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