Which Surface Functionalities are implied in Dust Toxicity?

  • Bice Fubini
Conference paper
Part of the NATO ASI Series book series (volume 85)

Abstract

Once inhaled a particle interacts at various stages, during its path in the respiratory tract, with cells, tissues and biological fluids. Each contact involves a specific functionality at the particle surface, so that the chemical features determining the overall pathogenicity of a given dust are probably more than one. Modulation of one surface property may thus end up in variation of the ultimate toxicity caused even by active surface sites which are unchanged. For this reason investigations on all surface properties of a toxic dust are required.

Keywords

Silicon Carbide Diatomaceous Earth Radical Release Silica Dust Silicon Carbide Whisker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Absher M.P., Trombley, L. Hemenway D.R. Mickey R.M., Leslie K.CX (1989) Biphasic cellular and tissue response of rat lungs after eight–day aerosol exposure to the silicon dioxide cristobalite. Am. J. Pathol,. 134,: 1243–1251.PubMedGoogle Scholar
  2. Bégin R, Dufresne A, Cantin A, Massé S, Sebastien P., Perrault G. (1989) Carborundum pneumoconiosis. Fibres in in the mineral activate macrophages to produce fibroblast growth factors and sustain the chronic inflammatory disease. Chest, 95: 842–849.PubMedCrossRefGoogle Scholar
  3. Birchall J.D., Stanley D.R., Mockford M.J., Pigott G.H., Pinto P.J. (1988) Toxicity of silicon carbide whiskers, J. Mat. Sci. Lett,. 7: 350–352.CrossRefGoogle Scholar
  4. Bolis V., Fubini B., Garrone E., Morterra C. (1989) Thermodynamic and vibrational characterisation of CO adsorption on variously pretreated anatase. J. Chem. Soc. Faraday, Trans, I, 85Google Scholar
  5. Bolis V., Fubini B., Marchese L., Martra G., Costa D. (1991) Hydrophilic and hydrophobic sites on dehydrated crystalline and amorphous silicas. J. Chem. Soc. Faraday, Tram., 87: 497–505.CrossRefGoogle Scholar
  6. Dufresne A., Perrault G., Sebastien P., Adnot A., Baril M. (1987) Morphology and surface characteristics of particulate from silicon carbide industries Am. Ind. Ass. J., 48: 718 –729.CrossRefGoogle Scholar
  7. Dzwigaj S., Pezerat H., Wastiaux A., Sebastien P., and Honnons S. (1993) Silica and silicosis mechanism. The role of surface properties of particles and of the silica–supported iron. Proceedings of the Eight International Conference on Occupational Lung Diseases Google Scholar
  8. Hurich et al. ed., ILO, Geneva, CH, p.1186–1191. Fubini B., Giamello E., Pugliese L., Volante M. (1989). Mechanically induced defects in quartz and their impact on pathogenicity. Solid State Ionics, 32–33: 334–343.Google Scholar
  9. Fubini B.,Giamello E., Volante M., and Bolis V. (1990). Chemical functionalities at the silica surface determining its reactivity when inhaled. Formation and reactivity of surface radicals. Toxicology and Industrial Health,, 6: 571–594.Google Scholar
  10. Fubini B., Bolis V., Giamello E. and Volante M. (1991) Chemical functionalities at the broken fibre surface relatable to free radicals production in “Mechanisms in Fibre, Carcinogenesis”, (R.C. Brown, J.A. Hoskins, N.F. Johnson, eds.) NATO ASI series, Plenum press, New York, p. 415–432.Google Scholar
  11. Fubini B. Bolis V., Cavenago A. and Ugliengo P. (1992) Ammonia and water as probes for the surface re reactivity of covalent solids: the case of cristobalite and silicon carbide. J.Chem.Soc. Faraday Trans., 88: 277–290.Google Scholar
  12. Fubini B., Volante M., Giamello E., Bolis V. (1993) The role of surface chemistry in the pathogenicity of mineral dusts and fibres: some open questions; in “Proceedings of the Eighth International Conference on Occupational Lung Diseases”, J.Hurich,M.Leasage, and A.David eds., ILO, Geneva, Switzerland, Vol. Ill, p. 1180–1185.Google Scholar
  13. Fubini B. (1993) The possible role of surface chemistry in the toxicity of inhaled fibers in “Fiber Toxicology”, D.B.Warheit ed., Academic Press, Chapter 11, p.229–257.85)Google Scholar
  14. Funahashi A., Schlneter O.P., Pintar K., Siegesmund K.A., Mandel G.S., Mandel N.S. (1984) Pneumoconiosis in workers exposed to Silicon Carbide., Am. rev. Respir. Dis,. 129 (4): 635–640.PubMedGoogle Scholar
  15. Giamello E., Fubini B., Volante M., Costa D. Surface oxygen radicals originating via redox reactions during the mechanical activation of crystalline Si02 in hydrogengen peroxide Colloids and Surfaces,, 45, 155–165, (1990).CrossRefGoogle Scholar
  16. Goodlick L.A., Kane A.B. (1986) Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages. Cancer Res,. 46: 5558–5566.Google Scholar
  17. Gulumian M, Van Wyk J. A. (1987) Hydroxyl radical production in the presence of fibres by a Fenton–type reaction. Chem. Biol. Interactions,, 62: 89–97CrossRefGoogle Scholar
  18. Hemenway D.R., Absher M.P., Trombley L., Vacek P.M. (1990) Comparative clearance of quartz and cristobalite from the lung. Am. Ind.Hyg.Assoc,. 51 (7): 363–369.CrossRefGoogle Scholar
  19. Hemenway D.R., Absher M.P, Fubini B and Bolis V. (1993a) What is the Relationship between Hemolytic Potential and Fibrogenicity of Mineral Dusts? Arch.Environ.Health Google Scholar
  20. Hemenway D.R., Absher M.P., Fubini B., Trombley L., Vacek P. Volante M., Cavenago A. Surface functionalities are related to biological response and transport of crystalline silica. 7th Intern. Symposium on Inhaled Particles BOHS, Edinburgh, 1991, Ann Occup.Hyg., in press.Google Scholar
  21. Honnons S., Oberson D., Wastiaux A., Dz Dzwigaj S., Pezerat H., Volante M., Fubini B., Porcher J.M. Pulmonary response to silica dust: the influence of crystalline structures and physico–chemical properties. Second International Symposium on Silica Silicosis and Cancer, San Francisco, October 1993Google Scholar
  22. Leanderson P, Soderkvist, Tagesson C, Axelson O (1988) Formation of 8– hydroxydeoxyguanosine by asbestos and man–made mineral fibers. Br. J. Ind. Med., 45: 309–311.PubMedGoogle Scholar
  23. Lund L.G. Aust A.E. (1990) Iron mobilization from asbestos by chelators and ascorbic acid. Arch Biochem.Biophys., 278: 60–64. (1991a) Mobilization of iron from crocidolite asbestos by certain chelators results in enhanced crocidolite–dependent oxygen consumption. Arch Biochem.Biophys., 287: 91–96. (1991b)PubMedCrossRefGoogle Scholar
  24. Iron catalyzed reactions may be responsible for the biochemical and biological effects of asbestos. Bk\factors, 3:83–89.Google Scholar
  25. Mossman B.T., Marsh J.P., Shatos M.A. (1986) Alteration of superoxide dismutase activity in tracheal epithelial cells by asbestos and inhibition of cytotoxicity by antioxidants. Lab, Invest., 54: 204–212.Google Scholar
  26. Oberdoster G., Ferin J., Soderholm S., Gelein R., Cox C., Baggs R. Morrow P.E. 7th Intern. Symposium on Inhaled Particles BOHS, Edinburgh, 1991, Ann Occup. Hyg., in press.Google Scholar
  27. Vallyathan,V., Shi, X., Dalai, N.S., Irr, W. and Castranova, V. (1988) Generation of free radicals from freshly fractured silica dust: potential role in acute silica–induced lung injury. Am. Rev. Respir. Dir,. 138, 1213–1219.Google Scholar
  28. Wastiaux A., Erre R., Pezerat H., Sebastien P. Quartz surface and fibrogenicity. 7th Intern. Symposium on Inhaled Particles BOHS, Edinburgh, 1991, Ann Occup. Hyg., in press.Google Scholar
  29. Wiecek E. The influence of real structure of quartz and cristobalite on their fibrogenic effects. Second International Symposium on Silica Silicosis and Cancer, San Francisco, October 1993Google Scholar
  30. Zalma R., Bonneau L., Jaurand M.C., Guignard J. and Pezerat H. (1987) Formation of oxyradicals by oxygen reduction arising from the surface activity of asbestos. Can. J. Chem,. 652, 338–2341.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Bice Fubini
    • 1
  1. 1.Dipartimento di Chimica Inorganica Chimica Fisica e Chimica dei MaterialiUniversità di TorinoTorinoItaly

Personalised recommendations