24. Hämophilie-Symposion pp 86-96 | Cite as
Chronische Hepatitis bei HBV-, HCV-, HIV-infizierten und koinfizierten Patienten mit angeborener Hämophilie A oder B
Conference paper
Zusammenfassung
Mit Verfügbarkeit des Anti-HCV-Tests [1–3] stellte sich heraus, daß von einer hohen Prävalenz von HCV-Antikörpern, insbesondere bei Vorliegen einer chronisch viralen Hepatitis, unter Blut- und Blutprodukt-Empfängern auszugehen ist [4–14]. Ein erheblicher Anteil HCV-Infizierter muß mit der Entwicklung einer chronisch aktiven Hepatitis bzw. einer Leberzirrhose rechnen [14–18]. Auch das hepatozelluläre Karzinom scheint bei HCV-seropositiven Patienten häufiger vorzukommen [19–24]. Viele parenteral HCV-infizierte Hämophile sind zugleich HIV-infiziert [16, 25–27]. Indes ist unklar, welchen Einfluß eine HIV-Infektion auf den Verlauf einer durch HCV verursachten Hepatitis ausübt. Die Befürchtung, HIV könne bei HCV-Infizierten zu einer überdurchschnittlich häufigen bzw. raschen Entwicklung eines Leberversagens führen [28–32], veranlaßte diese retrospektive Untersuchung, die Klinik und Laborparameter HCV-infizierter und HIV-seropositiver Patienten einerseits und HIV-seronegativer Hämophiler andererseits vergleicht.
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