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Improved Antileukemic Activity of the Combination of Ara-C with GM-CSF and IL-3 Fusion Protein (PIXY321)

  • Conference paper
Acute Leukemias V

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 37))

  • 72 Accesses

Abstract

Co-treatment with GM-CSF/IL3 fusion protein pIXY321 significantly increased apoptosis and the loss of clonogenic survival of HL-60 cells due to a treatment with high dose Ara-C (100 μM) for 4 hours or prolonged treatment with lose dose Ara-C (10 nM) for 5 days. In contrast, pIXY321 inhibited high dose Ara-C-in-duced apoptosis in CD34+ normal bone marrow cells. Combined treatment with staurosporine also enhanced Ara-C induced apoptosis in HL-60 cells. None of these modulations of Ara-C-induced apoptosis in the leukemic or normal cells was associated with appreciable alterations in intracellular p26BCL-2 levels.

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Author information

Authors and Affiliations

  1. Hematology/Oncology Division, Department of Medicine, Medical University of South Carolina, 29425, Charleston, SC, USA

    Kapil Bhalla, Ana Maria Ibrado, Gloria Bullock, Caroline Tang, Swapan Ray, Yue Huang & Vidya Ponnathpur

Authors
  1. Kapil Bhalla
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  2. Ana Maria Ibrado
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  3. Gloria Bullock
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  4. Caroline Tang
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  5. Swapan Ray
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  6. Yue Huang
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  7. Vidya Ponnathpur
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of Göttingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany

    W. Hiddemann  & W. Plunkett  & 

  2. Department of Internal Medicine, University of Münster, Albert-Schweitzer-Strasse 33, 48145, Münster, Germany

    T. Büchner

  3. Department of Pediatric Oncology, University of Münster, Albert-Schweitzer-Strasse 33, 48145, Münster, Germany

    J. Ritter

  4. Department of Internal Medicine, MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA

    B. Wörmann M.D., Ph.D.  & M. J. Keating M.D., B.S.  & 

  5. Koordinierungsstelle, Deutsche Krebsgesellschaft e.V., Thea-Bähnisch-Weg 12, 30657, Hannover, Germany

    U. Creutzig

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© 1996 Springer-Verlag Berlin Heidelberg

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Bhalla, K. et al. (1996). Improved Antileukemic Activity of the Combination of Ara-C with GM-CSF and IL-3 Fusion Protein (PIXY321). In: Hiddemann, W., et al. Acute Leukemias V. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78907-6_24

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  • DOI: https://doi.org/10.1007/978-3-642-78907-6_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78909-0

  • Online ISBN: 978-3-642-78907-6

  • eBook Packages: Springer Book Archive

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