Cellular and Molecular Aspects of Circadian Oscillators: Models and Mechanisms for Biological Timekeeping

  • L. N. EdmundsJr.
Chapter

Abstract

Several approaches to elucidate the nature of biological clocks, particularly circadian oscillators, have emerged over the years (Hastings and Schweiger 1976; Edmunds 1988). These include the attempt to locate the anatomical loci responsible for generating these periodicities, efforts to trace the entrainment pathway for light signals (and other zeitgebers) from the photoreceptor(s) to the clock itself, the experimental dissection of the clock using chemicals and metabolic inhibitors and employing the exciting new techniques of molecular genetics, and the characterization of the coupling pathways and the transducing mechanisms between the clock(s) and the overt rhythmicities (hands) it drives. The results obtained by these experimental lines of attack, in turn, have provided the grist for several classes of biochemical and molecular model for autonomous circadian oscillators (COs).

Keywords

Circadian Rhythm Circadian Clock Clock Gene Compound Action Potential Circadian Oscillator 
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