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Measles Virus pp 117-134 | Cite as

Immune Responses During Measles Virus Infection

  • D. E. Griffin
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 191)

Abstract

The immune responses elicited by measles virus (MV) in many ways define the epidemiology and the illnesses produced by infection. During a study of the 1886 epidemic of measles in the Faroe Islands, the young Danish physician Peter Panum identified not only the highly infectious nature of the virus, but also the 14 day incubation period before the onset of the rash, the severity of the disease in infants and the presence of lifelong immunity in the absence of reexposure in elderly residents (Panum 1938). In 1908 another observant physician, von Pirquet, reported the loss of skin test reactivity and the reactivation of tuberculosis after measles that occurred in the residents of a Viennese tuberculosis sanitarium (VON Pirquet 1908). In 1790 James Lucas, a surgeon from Leeds, described the first case of post-measles encephalomyelitis (Lucas 1790). Thus, by early in the twentieth century most of the features of the disease that we now seek to understand, using the knowledge and tools of modern immunology, had been established.

Keywords

Major Histocompatibility Complex Class Cellular Immune Response Measle Virus Measle Vaccine Subacute Sclerosing Panencephalitis 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • D. E. Griffin
    • 1
  1. 1.Departments of Medicine and NeurologyJohns Hopkins University School of MedicineBaltimoreUSA

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