Molecular Diversity of Mammalian Adenylyl Cyclases: Functional Consequences

  • R. T. Premont
  • J. Chen
  • O. Jacobowitz
  • R. Iyengar
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 108 / 2)

Abstract

Adenylyl cyclase (EC 4.6.1.1) converts MgATP into 3′,5′-cyclic AMP (cAMP) and pyrophosphate. Since the initial characterization of the enzyme by Sutherland and coworkers in 1962 adenylyl cyclase activities have been identified in organisms ranging from bacteria to man. The structure and regulation of these adenylyl cyclase enzymes as well as the regulatory role of the cAMP produced varies considerably across this evolutionary distance.

Keywords

Adenylyl Cyclase Adenylyl Cyclase Activity Heterologous Desensitization Adenylyl Cyclase System Putative Protein Kinase 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • R. T. Premont
  • J. Chen
  • O. Jacobowitz
  • R. Iyengar

There are no affiliations available

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