Transgenic Models to Study Diseases of the Nervous System: An In Vivo Approach to Dissect Complex Pathogenetic Networks

  • L. Mucke
Conference paper


Diseases of the nervous system often pose particular challenges, both in terms of their pathogenetic complexity and their refractoriness to conventional therapeutic strategies. Multiple sclerosis, Alzheimer’s disease (AD), and the human immunodeficiency virus 1 (HIV-1) associated cognitive/motor complex dramatically illustrate this point. Because many disease processes that afflict the central nervous system (CNS) evolve slowly, the neuropathologist is often confronted with postmortem material that reflects the intricate combination of causative and compensatory processes. Unfortunately, many features of CNS diseases are also difficult to dissect with in vitro models because of the extensive interactions between different types of predominantly nondividing cells that characterize the adult CNS. Nevertheless, both in vitro models and the pathologic analysis of nervous tissue have provided important leads as to which cellular activities, gene products, infectious agents, or chemical compounds may constitute potential etiologic factors in the development of neurologic illnesses.


Major Histocompatibility Complex Glial Fibrillary Acidic Protein Experimental Allergic Encephalomyelitis Transgenic Model Adult Central Nervous System 
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© Springer-Verlag Berlin Heidelberg 1993

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  • L. Mucke

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