Bone Remodeling and Bone Structure

  • E. F. Eriksen
  • A. Vesterby
  • M. Kassem
  • F. Melsen
  • L. Mosekilde
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 107)


Bone remodeling constitutes the lifelong renewal process of bone whereby the mechanical integrity of the skeleton is preserved. It implies the continuous removal of bone (bone resorption) followed by synthesis of new bone matrix and subsequent mineralization (bone formation). Moreover, bone remodeling is an integral part of the calcium homeostatic system together with the kidneys and the gut. The ever ongoing removal of old bone by osteoclastic resorption and subsequent coupled osteoblastic formation of new bone leads to liberation of calcium and matrix constituents to serum.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • E. F. Eriksen
  • A. Vesterby
  • M. Kassem
  • F. Melsen
  • L. Mosekilde

There are no affiliations available

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