Enteroviral Heart Muscle Disease: Current Molecular Studies and Future Research

  • L. Cunningham
  • P. J. Richardson
  • L. C. Archard

Abstract

Enterovirus infection, particularly with Coxsackie B virus serotypes, has been associated with heart muscle disease by serological studies and the use of mouse models. A study in Scotland by Grist and Bell [1] provided comprehensive serological data correlating enterovirus infection with myocarditis. However, the association of these viruses with dilated cardiomyopathy was less well established and was based mainly on the observation of high titres of neutralising antibody in cases of sudden onset disease (see below); this led to the proposal that dilated cardiomyopathy is a progression from an enteroviral myocarditis, itself a sequela of a common, frequently trivial or subclinical, enteric infection [2].

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References

  1. 1.
    Grist NR, Bell EJ (1974) A six year study of Coxsackie virus B infections in heart disease. J Hyg 73: 165–172CrossRefGoogle Scholar
  2. 2.
    Goodwin JF (1983) Myocarditis as a possible cause of cardiomyopathy. In: Just H, Schuster HP (eds) Myocarditis. Cardiomyopathy. Springer, Berlin Heidelberg New York, pp 7–11CrossRefGoogle Scholar
  3. 3.
    Grist NR, Bell EJ (1978) Enteroviruses in human disease. In: Melnick JL (ed) Progress in medical virology. Karger, Basel, pp 114–157Google Scholar
  4. 4.
    Morgan-Capner P, Richardson PJ, McSorley C, Daly K, Pattison JR (1984) Virus investigations in heart muscle disease. Springer, Berlin Heidelberg New York, pp 95–115Google Scholar
  5. 5.
    Cambridge G, MacArthur CGC, Waterson AP, Goodwin JF, Oakley CM (1979) Antibodies to Coxsackie B viruses in primary congestive cardiomyopathy, Br Heart J 41: 13–23CrossRefGoogle Scholar
  6. 6.
    EI-Hagrassy MMO, Banatvala JE, Coltart DJ (1980) Coxsackie B specific IgM responses in patients with cardiac and other disease. Lancet 2: 1160–1162PubMedCrossRefGoogle Scholar
  7. 7.
    McCartney RA, Banatvala JE, Bell EJ (1986) Routine use of mu-antibody-capture ELISA for the serological diagnosis of Coxsackie B virus infections. J Med Virol 19: 205–212PubMedCrossRefGoogle Scholar
  8. 8.
    Muir P, Nicholson F, Tilzey AJ et al. (1989) Chronic relapsing pericarditis and dilated cardiomyopathy: serological evidence of persistent enterovirus infection. Lancet I: 804–807Google Scholar
  9. 9.
    Woodruff JF (1980) Viral myocarditis: a review. Am J Pathol 101: 425–484PubMedGoogle Scholar
  10. 10.
    Huber SA, Lodge PA, Job LP (1984) The role of virus and immune mediated cardiocyte injury in Coxsackie B3 induced myocarditis In: Bolte HD (ed) Viral heart disease. Springer, Berlin Heidelberg New York, pp 64–73Google Scholar
  11. 11.
    Reyes MP, Ho KL, Smith FE, Lerner AM (1981) A mouse model of dilated type cardiomyopathy due to Coxsackie B3 virus. J Infect Dis 144: 232–236PubMedCrossRefGoogle Scholar
  12. 12.
    Klump WM, Bergmann I, Muller BC, Ameis D, Kandolf R (1990) Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA: two initial 5’ uridine residues are regained during plus-strand RNA synthesis. J Virol 64: 1573–1583PubMedGoogle Scholar
  13. 13.
    Stalhandske PO, Lindberg M, Pettersson U (1984) Replicase gene of Coxsackievirus B3. J Virol 51: 742–746PubMedGoogle Scholar
  14. 14.
    Kaczmarek L, Calabretta B, Baserga R (1985) Expression of cell-cycle-dependent genes in phytohemagglutinin-stimulated human lymphocytes. Proc Natl Acad Sci USA 82: 5375–5379PubMedCrossRefGoogle Scholar
  15. 15.
    Bowles NE, Rose ML, Taylor P et al. (1989) End-stage dilated cardiomyopathy: persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response. Circulation 80: 1128–1136PubMedCrossRefGoogle Scholar
  16. 16.
    Bowles NE, Richardson PJ, Olsen EG, Archard LC (1986) Detection of Coxsackie-B-virusspecific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 1: 1120–1123PubMedCrossRefGoogle Scholar
  17. 17.
    Archard LC, Richardson PJ, Olsen EG, Dubowitz V, Sewry C, Bowles NE (1987) The role of Coxsackie B viruses in the pathogenesis of myocarditis, dilated cardiomyopathy and inflammatory muscle disease. Biochem Soc Symp 53: 51–62PubMedGoogle Scholar
  18. 18.
    Kandolf R, Amies D, Kirschner P et al. (1987) In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease. Proc Natl Acad Sci USA 84: 6272–6276PubMedCrossRefGoogle Scholar
  19. 19.
    Rotbart HA, Abzug MJ, Murray RS, Murphy NL, Levin MJ (1988) Intracellular detection of sense and antisense enteroviral RNA by in situ hybridization; J Virol Methods 22: 295–301Google Scholar
  20. 20.
    Cunningham L, Bowles NE, Lane RI, Dubowitz V, Archard LC (1990) Persistence of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of positive and negative strands of enteroviral RNA. J Gen Virol 71: 1399–1402PubMedCrossRefGoogle Scholar
  21. 21.
    Archard LC, Bowles NE, Cunningham L, Freeke CA, Olsen EGJ, Rose ML, Meany B, Why HJF, Richardson PJ (1991) Molecular probes for detection of persisting enterovirus infection of human hearts and their prognostic value. Eur Heart J 12 (Suppl D): 56–59PubMedGoogle Scholar
  22. 22.
    Andino R, Rieckhof GE, Baltimore D (1990) A functional ribonucleoprotein complex forms around the 5’ end of poliovirus RNA. Cell 63: 369–380PubMedCrossRefGoogle Scholar
  23. 23.
    Oldstone MB (1989) Viral alteration of cell function. Sci Am 261: 42–48PubMedCrossRefGoogle Scholar
  24. 24.
    Chatterjee NK, Nejman C (1988) Insulin mRNA content in pancreatic beta cells of Coxsackie virus B4-induced diabetic mice. Mol Cell Endocrinol 55: 193–202PubMedCrossRefGoogle Scholar
  25. 25.
    Otto MJ, Fox MP, Fancher MJ, Kuhrt MF, Diana GC, McKinlay MA (1985) In vitro activity of WIN 51711: a new broad spectrum antipicornavirus drug. Antimircrob Agents Chemother 27: 883–886Google Scholar
  26. 26.
    Hirsch MS, Kaplan JC (1990) Antiviral agents. In: Fields BN (ed) Virology. Raven Press, New York, pp 90: 441–468Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • L. Cunningham
  • P. J. Richardson
  • L. C. Archard

There are no affiliations available

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