pp 275-288

Enteroviral Heart Muscle Disease: Current Molecular Studies and Future Research

  • L. Cunningham
  • , P. J. Richardson
  • , L. C. Archard

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Enterovirus infection, particularly with Coxsackie B virus serotypes, has been associated with heart muscle disease by serological studies and the use of mouse models. A study in Scotland by Grist and Bell [1] provided comprehensive serological data correlating enterovirus infection with myocarditis. However, the association of these viruses with dilated cardiomyopathy was less well established and was based mainly on the observation of high titres of neutralising antibody in cases of sudden onset disease (see below); this led to the proposal that dilated cardiomyopathy is a progression from an enteroviral myocarditis, itself a sequela of a common, frequently trivial or subclinical, enteric infection [2].