Selective Inhibition of Polymorphonuclear Leukocyte Oxidative Burst and CD11b/CD16 Expression by Prostaglandin E2
Following injury, prostaglandin E2 (PGE2) is released from stimulated mononuclear cells. Abnormally elevated levels of PGE2 have been measured in supernatants of macrophages obtained from burned mice , and in posttraumatic patients PGE2 suppresses interleukin-2 production by T lymphocytes . Human polymorphonuclear leukocytes (PMN) contain on their surface an adhesion glycoprotein, identified as the receptor for C3bi (CR3) . CR3 is a heterodimer composed of a 170-kDa α-chain (CD11b) and an invariant 95-kDa β-chain (CD18). Also contained on the PMN surface are several receptors for the Fc portion of immunoglobulins (FcγR). In particular, the 50 to 70-kDa FcγR III is a low-affinity receptor that binds immune-complexed IgG and has been designated CD16 . Together, these two surface proteins have been used to identify phenotypic subclasses of PMN .
KeywordsPhorbol Myristate Acetate Polymorphonuclear Leukocyte Phorbol Myristate Acetate Human Polymorphonuclear Leukocyte Oxidative Burst Activity
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