Transgenic Mice Carrying the Human MDR 1 Gene: Reliable In Vivo Probes to Examine Multidrug Resistance
Conference paper
Abstract
Resistance to chemotherapy poses an ultimate obstacle to curing human cancer which is not amenable to definitive surgical or radiation treatment. Numerous investigations have uncovered processes instigating a clinically relevant broad cross-resistance spectrum to natural product cytotoxic compounds without striking functional or structural similarities, termed multiple drug resistance (MDR) [15]. The compiled evidence implies that the so-called multidrug transporter, P-170 glycoprotein, encoded by the human MDR 1 gene [23], is sufficient to produce MDR of cancer cells [8]. Its functions predominantly involve the rapid extrusion of hydrophobic chemotherapeutic agents from the cell before they can exert their designated actions [11].
Keywords
Multi Drug Resistance Multiple Drug Resistance White Blood Count Bone Marrow Toxicity Multidrug Transporter
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