Modern Trends in Human Leukemia IX pp 311-315 | Cite as
Immunological Self-Nonself Discrimination and Numerous Peptide Fragments Shared by Unrelated Proteins
Conference paper
Abstract
Ever since the X-ray crystallographic analysis of a class I major histocompatibility complex (MHC) antigen revealed the presence of an alien peptide fragment sandwiched between its two parallel α- helices [1], the immunological self became a multitude of such pepdtide fragments, usually 15–20 residues long, derived from host proteins after intracellular processing. For the mainly intrathymic education of self to cytotoxic T cells, these fragments are presented in association with class I MHC antigens, while for the education of helper T cells, they are presented with class II MHC antigens.
Keywords
Major Histocompatibility Complex Peptide Fragment Host Protein Unrelated Protein Virus Matrix Protein
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© Springer-Verlag Berlin Heidelberg 1992