Hemorrhagic Transformation in the Natural History of Acute Embolic Stroke
Interest generated by the potential benefits of thrombolytic treatment (especially tissue-type plasminogen activator, t-PA) for acute stroke is tempered by the serious complication of intracranial bleeding. The risks of intracranial bleeding are presently being assessed in several United States and European pilot trials, of different design, using intravenously administered t-PA in acute stroke. Serious intracranial bleeding in these studies refers to bleeding which causes clinical neurologic deterioration not attributable to the original stroke. When the pilot phase of these investigations is complete, control groups of untreated patients will help us compare, in a scientific fashion, intracranial bleeding associated with t-PA. Meanwhile, observations on the natural incidence and clinical computed tomography (CT) features of hemorrhagic transformation (HT) in untreated patients with acute embolic stroke will have to serve as a framework for comparison with acute stroke patients treated with thrombolytic agents.
KeywordsIntracranial Bleeding Compute Tomography Study Hemorrhagic Transformation Cerebral Embolism Embolic Stroke
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