Growth factors as transforming proteins

  • Carl-Henrik Heldin
  • Bengt Westermark
Chapter
Part of the EJB Reviews book series (EJB REVIEWS, volume 1989)

Abstract

The growth of cells in culture is controlled by stimulatory or inhibitory factors. More than 20 different polypeptide growth factors have been structurally and functionally characterized, including cloning of their cDNAs (Table 1). The total number of polypeptide growth, factors is likely to be considerably higher, since additional factors, that have not yet been fully characterized, are known from their specific biological activities. There are also factors that specifically inhibit cell growth, e.g. transforming growth factor β (TGF-β) [1], interferons [2] and tumor necrosis factor [3]. Moreover, the same factor may, depending on cell type and culture conditions, act both as a growth factor and a growth inhibitor [4a]

Keywords

Fibroblast Growth Factor Autocrine Loop Hemopoietic Cell AUTOCRINE Growth Factor Autocrine Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CSF

colony-stimulating factor

EGF

epidermal growth factor

FGF

fibroblast growth factor

HTLV

human T-cell leukemia virus

IGF

insulin-like growth factor

IL

interleukin

MGSA

melanoma growth stimulatory activity

PDGF

platelet-derived growth factor

SSV

simian sarcoma virus

TGF

transforming growth factor

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References

  1. 1.
    Sporn, M. B., Roberts, A. B., Wakefield, L. M. & de Crombrugghe (1987) J. Cell. Biol. 105, 1039–1045.PubMedGoogle Scholar
  2. 2.
    Romeo, G., Fiorucci, G. & Rossi, G. B. (1989) Trends Genet. 5, 19–24.PubMedGoogle Scholar
  3. 3.
    Old, L. (1988) Sci. Am. 254, 41–49.Google Scholar
  4. 4a.
    a. Sporn, M. B. & Roberts, A. B. (1985) Nature 313, 745–747.PubMedGoogle Scholar
  5. 4b.
    b. Yarden, Y. & Ullrich, A. (1988) Annu. Rev. Biochem. 57, 443–478.PubMedGoogle Scholar
  6. 5.
    Heldin, C.-H., Ernhmd, A., Rorsman, C. & Rönnstrand, L. (1989) J. Biol. Chem. 264, 8905–8912.PubMedGoogle Scholar
  7. 6.
    Schlesinger, J. (1986) J. Cell. Biol. 103, 2067–2072.Google Scholar
  8. 7.
    Hunter, T. & Cooper, J. A. (1985) Annu. Rev. Biochem. 54, 897–930.PubMedGoogle Scholar
  9. 8.
    Morrison, D. K., Kaplan, D. R., Rapp, U. & Roberts, T. M. (1988) Proc. Natl Acad. Sci. USA 85, 8855–8859.PubMedGoogle Scholar
  10. 9.
    Ralston, R. & Bishop, J. M. (1985) Proc. Natl Acad. Sci. USA 82, 7845–7849.PubMedGoogle Scholar
  11. 10.
    Gould, K. L. & Hunter, T. (1988) Mol. Cell. Biol. 8, 3345–3356.PubMedCentralPubMedGoogle Scholar
  12. 11.
    Nishizuka, Y. (1984) Nature 308, 693–698.PubMedGoogle Scholar
  13. 12.
    Berridge, M. J. & Irvine, R. F. (1984) Nature 312, 315–321.PubMedGoogle Scholar
  14. 13.
    Wahl, M. I., Daniel, T. O. & Carpenter, G. (1988) Science 241, 968–970.PubMedGoogle Scholar
  15. 14.
    Coughlin, S. R., Lee, W. M. F., Williams, P. W., Giels, G. M. & Williams, L. T. (1985) Cell 43, 243–251.PubMedGoogle Scholar
  16. 15.
    Cochran, B. H., Reffel, A. C. & Stiles, C. D. (1983) Cell 33, 939–947.PubMedGoogle Scholar
  17. 16.
    Linzer, D. F. H. & Nathans, D. (1983) Proc. Natl Acad. Sci. USA 80, 4271–4275.PubMedGoogle Scholar
  18. 17.
    Ferrari, S. & Baserga, R. (1987) Bioessays 7, 9–13.PubMedGoogle Scholar
  19. 18.
    Almendral, J. M., Sommer, D., MacDonald-Bravo, H., Bruckhardt, J., Perera, J. & Bravo, R. (1988) Mol. Cell. Biol. 8, 2140–2148.PubMedCentralPubMedGoogle Scholar
  20. 19.
    Heldin, C.-H., Betsholtz, C., Claesson-Welsh, L. & Westermark, B. (1987) Biochim. Biophys. Acta 907, 219–244.PubMedGoogle Scholar
  21. 20.
    Temin, H. M. (1967) in Growth regulating substances for animal cells in cultures (Defendi, V. & Stoker, M., eds) vol. 7, pp. 103–116, The Wistar Symposium Monograph, Wistar Institute Press, Philadephia.Google Scholar
  22. 21.
    Sporn, M. B. & Todaro, G. J. (1980) N. Eng. J. Med. 303, 878–880.Google Scholar
  23. 22.
    Sporn, M. B. & Roberts, A. B. (1985) Nature 313, 745–747.PubMedGoogle Scholar
  24. 23.
    Heldin, N. E., Gustafsson, B., Claesson-Welsh, L., Hammacher, A., Heldin, C.-H. & Westermark, B. (1988) Proc. Natl Acad. Sci. USA 85, 9302–9306.PubMedGoogle Scholar
  25. 24.
    Pierce, J. H., Ruggiero, M., Fleming, T. P., Di Fiore, P. P., Greenberger, J. S., Varticovski, L., Schlessinger, J., Rovera, G. & Aaronson, S. A. (1988) Science 239, 628–631.PubMedGoogle Scholar
  26. 25.
    Heldin, C.-H., Wasteson, Å. & Westermark, B. (1985) Mol Cell Endocrinal 39, 169–187.Google Scholar
  27. 26.
    Ross, R., Raines, E. W. & Bowen-Pope, D. F. (1987) Cell 46, 155–169.Google Scholar
  28. 27.
    Heldin, C.-H., Johnsson, A., Wennergren, S., Wernstedt, C., Betsholtz, C. & Westermark, B. (1986) Nature 319, 511–514.PubMedGoogle Scholar
  29. 28.
    Hammacher, A., Hellman, U., Johnsson, A., Östman, A., Gunnarsson, K., Westermark, B., Wasteson, Â. & Heldin, C.-H. (1988) J. Biol Chem. 263, 16493–16498.PubMedGoogle Scholar
  30. 29.
    Stroobant, P. & Waterfield, M. D. (1984) EM BO J. 3, 2963–2967.Google Scholar
  31. 30.
    Nistér, M., Hammacher, A., Mellström, K., Siegbahn, A., Rönnstrand, L., Westermark, B. & Heldin, C.-H. (1988) Cell 52, 791–799.PubMedGoogle Scholar
  32. 31.
    Kazlauskas, A., Bowen-Pope, D. F., Seifert, R., Hart, C. E. & Cooper, J. A. (1988) EM BO J. 7, 3727–3735.Google Scholar
  33. 32.
    Pringle, N., Collarini, E. J., Mosley, M. J., Heldin, C.-H., Westermark, B. & Richardson, W. D. (1989) EM BO J. 4, 1049–1056.Google Scholar
  34. 33.
    Heldin, C.-H., Bäckström, G., Östman, A., Hammacher, A., Rönnstrand, L., Rubin, K., Nistér, M. & Westermark, B. (1988) EM BO J. 7, 1387–1392.Google Scholar
  35. 34.
    Hart, C. E., Forstrom, J. D., Kelly, R. A., Smith, E., Ross, R., Murray, M. J. & Bowen-Pope, D. F. (1988) Science 240, 1529–1532.PubMedGoogle Scholar
  36. 35.
    Escobedo, J. A., Navankasatussas, S., Cousens, L. S., Coughlin, S. R., Bell, G. I. & Williams, L. T. (1988) Science, 240, 1532–1534.PubMedGoogle Scholar
  37. 36.
    Devare, S. G., Reddy, E. P., Law, J. D., Robbins, K. C. & Aaronson S. A. (1983) Proc. Natl Acad. Sci. USA 80, 731–735.PubMedGoogle Scholar
  38. 37.
    Besmer, P., Snyder, H. W. Jr, Murphy, J. E., Hardy, W. D. Jr & Parodi, A. (1983) J. Virol 46, 606–613.PubMedCentralPubMedGoogle Scholar
  39. 38.
    Westermark, B., Betsholtz, C., Johnsson, A. & Heldin, C.-H. (1987) in Viral carcinogens (Kjeldgaard, N. O. & Forschhammer, J., eds) pp. 445–457, Munksgaard, Copenhagen.Google Scholar
  40. 39.
    Deuel, T. F., Huang, J. S., Huang, S. S., Stroobant, P. & Waterfield, M. (1983) Science 221, 1348–1350.PubMedGoogle Scholar
  41. 40.
    Bowen-Pope, D. F., Vogel, A. & Ross, R. (1984) Proc. Natl Acad. Sci. USA 81, 2396–2400.PubMedGoogle Scholar
  42. 41.
    Owen, A. J., Pantazis, P. & Antoniades, H. N. (1984) Science 225, 54–56.PubMedGoogle Scholar
  43. 42.
    Garrett, J. S., Coughlin, S. R., Niman, H. L., Tremble, P. M., Giels, G. M. & Williams, L. T. (1984) Proc. Natl Acad. Sci. USA 81, 7466–7410. PubMedGoogle Scholar
  44. 43.
    Huang, J. S., Huang, S. S. & Deuel, T. F. (1984) Cell 39, 79–87.PubMedGoogle Scholar
  45. 44.
    Johnsson, A., Betsholtz, C., von der Helm, K., Heldin, C.-H. & Westermark, B. (1985) Proc. Natl Acad. Sci. USA 82, 1721–1725.PubMedGoogle Scholar
  46. 45.
    Leal, F., Williams, L. T., Robbins, K. C. & Aaronson, S. A. (1985) Science 230, 327–330.PubMedGoogle Scholar
  47. 46.
    Johnsson, A., Betsholtz, C., Heldin, C.-H. & Westermark, B. (1985) Nature 317, 438–440.PubMedGoogle Scholar
  48. 47.
    Betsholtz, C., Johnsson, A., Heldin, C.-H. & Westermark, B. (1986) Proc. Natl Acad. Sci. USA 83, 6440–6444.PubMedGoogle Scholar
  49. 48.
    Hannink, M. & Donoghue, D. J. (1984) Science 130, 1197–1199.Google Scholar
  50. 49.
    King, C. R., Giese, N. A., Robbins, K. C. & Aaronson, S. A. (1985) Proc. Natl Acad. Sci. USA 82, 5295–5299.PubMedGoogle Scholar
  51. 50.
    Gazit, A., Igarashi, H., Chiu, I. M., Srinivasan, A., Yaniv, A., Tronick, S. R., Robbins, K. C. & Aaronson, S. A. (1984) Cell 39, 80–97.Google Scholar
  52. 51.
    Clarke, M. F., Westin, E., Schmidt, D., Josephs, S. F., Ratner, L., Wong-Staal, F., Gallo, R. C. & Reitz, M. S. (1984) Nature 308, 464–467.PubMedGoogle Scholar
  53. 52.
    Josephs, S. F., Ratner, L., Clarke, M. F., Westin, E. H., Reitz, M. S. & Wong-Staal, F. (1984) Science 225, 636–639.PubMedGoogle Scholar
  54. 53.
    Bywater, M., Rorsman, F., Bongcam-Rudioff, E., Mark, G., Hammacher, A., Heldin, C.-H., Westermark, B. & Betsholtz, C. (1988) Mol. Cell. Biol 8, 2753–2762.PubMedCentralPubMedGoogle Scholar
  55. 54.
    Beckmann, M. P., Betsholtz, C., Heldin, C.-H., Westermark, B., Di Marco, E., Di Fiore, P. P., Robbins, K. C. & Aaronson, S. A. (1988) Science, 241, 1346–1349.PubMedGoogle Scholar
  56. 55.
    Nistér, M., Libermann, T., Betsholtz, C., Pettersson, M., Claesson-Welsh, L., Heldin, C.-H., Schlessinger, J. & Westermark, B. (1988) Cancer Res. 48, 3910–3918.PubMedGoogle Scholar
  57. 56.
    Hammacher, A., Nistér, M., Westermark, B. & Heldin, C.-H. (1988) Eur. J. Biochem. 176, 179–186.PubMedGoogle Scholar
  58. 57.
    Hermansson, M., Nistér, M., Betsholtz, C., Heldin, C.-H., Westermark, B. & Funa, K. (1988) Proc. Natl Acad. Sci. USA 85, 7748–7752.PubMedGoogle Scholar
  59. 58.
    Rozengurt, E., Sinnett-Smith, J. & Taylor-Papadimitriou, J. (1985) Int. J. Cancer 36, 247–252.PubMedGoogle Scholar
  60. 59.
    Perez, R., Betsholtz, C., Westermark, B. & Heldin, C.-H. (1987) Cancer Res. 47, 3425–3429.Google Scholar
  61. 60.
    Bronzert, D. A., Pantazis, P., Antoniades, H. N., Kasid, A., Davidson, N., Dickson, R. B. & Lippman, M. E. (1987) Proc. Natl Acad. Sci. USA 84, 5763–5767.PubMedGoogle Scholar
  62. 61.
    Söderdahl, G., Betsholtz, C., Johansson, A., Nilsson, K. & Berg, J. (1988) Int. J. Cancer. 41, 636–641.PubMedGoogle Scholar
  63. 62.
    Westermark, B., Johnsson, A., Paulsson, Y., Betsholtz, C., Heldin, C.-H., Herlyn, M., Rodeck, U. & Koprowski, H. (1986) Proc. Natl Acad. Sci. USA 83, 7197–7200.PubMedGoogle Scholar
  64. 63.
    Alitalo, R., Andersson, L. C., Betsholtz, C., Nilsson, K., Westermark, B., Heldin, C.-H. & Alitalo, K. (1987) EM BO J. 6, 1213–1218.Google Scholar
  65. 64.
    Pantazis, P., Sariban, E., Kufe, D. & Antoniades, H. N. (1986) Proc. Natl Acad. Sci. USA 83, 6455–6459.PubMedGoogle Scholar
  66. 65.
    Bringman, T. S., Lindquist, P. B. & Derynck, R. (1987) Cell 48, 429–440.PubMedGoogle Scholar
  67. 66.
    Gentry, L. E., Twardzik, D. R., Lim, G. J., Ranchalis, J. E. & Lee, D. C. (1987) Mol. Cell. Biol. 7, 1585–1591.PubMedCentralPubMedGoogle Scholar
  68. 67.
    Teixidó, J., Gilmore, R., Lee, D. C. & Massagué, J. (1987) Nature 326, 883–885.PubMedGoogle Scholar
  69. 68.
    Gray, A., Dull, T. J. & Ullrich, A. (1983) Nature 303, 722–725.PubMedGoogle Scholar
  70. 69.
    Scott, J., Urdea, M., Quiroga, M., Sanchez-Pescador, R., Fong, N., Selby, M., Rutter, W. J. & Bell, G. I. (1983) Science 221, 236–240.PubMedGoogle Scholar
  71. 70.
    Stroobant, P., Rice, A. P., Gullick, W. J., Chen, D. J., Kerr, I. M. & Waterfield, M. (1985) Cell 42, 383–393.PubMedGoogle Scholar
  72. 71.
    Twardzik, D. R., Brown, J. P., Ranchalis, J. E., Todaro, G. J. & Moss, B. (1985) Proc. Natl Acad. Sci. USA 82, 5300–5304.PubMedGoogle Scholar
  73. 72.
    De Larco, J. E. & Todaro, G. J. (1978) Proc. Natl Acad. Sci. USA 75, 4001–4005.PubMedGoogle Scholar
  74. 73.
    Todaro, G. J., De Larco, J. E., Marquardt, H., Bryant, M. L., Sherwin, S. A. & Sliski, A. H. (1979) in Hormones and cell culture, book A (Sato, G. H. & Ross, R., eds) vol. 6, pp. 113–127, Cold Spring Harbor, Conferences on Cell Proliferation, Cold Spring Harbor, New York.Google Scholar
  75. 74.
    Ozanne, B., Fulton, R. J. & Kaplan, P. L. (1980) J. Cell Physiol. 105, 163–180.PubMedGoogle Scholar
  76. 75.
    Twardzik, D. R., Todaro, G. J., Marquardt, H., Reynolds, F. H. Jr & Stephenson, J. R. (1982) Science 216, 894–896.PubMedGoogle Scholar
  77. 76.
    Twardzik, D. R., Todaro, G. J., Reynolds, F. H. Jr & Stephenson, J. R. (1983) Virology 124, 201–207.PubMedGoogle Scholar
  78. 77.
    Marquardt, H., Hunkapiller, M. W., Hood, L. E., Twardzik, D. R., De Larco, J. E., Stephenson, J. R. & Todaro, G. J. (1983) Proc. Natl Acad. Sci. USA 80, 4684–4688.PubMedGoogle Scholar
  79. 78.
    Kaplan, P. L. & Ozanne, B. (1982) Virology 123, 372–380.PubMedGoogle Scholar
  80. 79.
    Todaro, G. J., Fryling, C. & De Larco, J. E. (1980) Proc. Natl Acad. Sci. USA 77, 5258–5262.PubMedGoogle Scholar
  81. 80.
    Derynck, R., Roberts, A. B., Winkler, M. E., Chen, E. Y. & Goeddel, D. V. (1984) Cell 38, 287–297.PubMedGoogle Scholar
  82. 81.
    Derynck, R., Goeddel, D. V., Ullrich, A., Gutterman, J. U., Williams, R. D., Bringman, T. S. & Berger, W. H. (1987) Cancer Res. 47, 707–712.PubMedGoogle Scholar
  83. 82.
    Sato, M., Yoshida, H., Hayashi, Y., Miyakami, K., Bando, T., Yanagawa, T., Yuna, Y., Azuma, M. & Ueno, A. (1985) Cancer Res. 45, 6160–6167.PubMedGoogle Scholar
  84. 83.
    Anzano, M. A., Roberts, A. B., Smith, J. M., Sporn, M. B. & DeLarco, J. E. (1983) Proc. Natl Acad. Sci. USA 80, 6264–6268.PubMedGoogle Scholar
  85. 84.
    van Zoelen, E. J. J, van Oostward, T. M. J. & de Laat, S. W. (1988) J. Biol. Chem. 263, 64–68.PubMedGoogle Scholar
  86. 85.
    Kaplan, P. L., Andersson, M. & Ozanne, B. (1982) Proc. Natl Acad. Sci. USA 79, 485–489.PubMedGoogle Scholar
  87. 86.
    McKay, I., Malone, P., Marshall, C. J. & Hall, A. (1986) Mol. Cell. Biol. 6, 3382–3387.PubMedCentralPubMedGoogle Scholar
  88. 87.
    Rosenthal, A., Lindquist, P. B., Bringman, T. S., Goeddel, D. V. & Derynck, R. (1986) Cell 46, 301–309.PubMedGoogle Scholar
  89. 88.
    Finzi, E., Fleming, T., Segatto, O., Pennington, C. Y., Bringman, T. S., Derynck, R. & Aaronson, S. A. (1987) Proc. Natl Acad. Sci USA. 84, 3733–3737.PubMedGoogle Scholar
  90. 89.
    Watanabe, S., Lazar, E. & Sporn, M. B. (1987) Proc. Natl Acad. Sci. USA 84, 1258–1262.PubMedGoogle Scholar
  91. 90.
    Stern, D. F., Hare, D. L., Cecchini, M. A. & Weinberg, R. A. (1987) Science 235, 321–324.PubMedGoogle Scholar
  92. 91.
    Smith, J. J., Derynck, R. & Korc, M. (1987) Proc. Natl Acad. Sci. USA 84, 7567–7570.PubMedGoogle Scholar
  93. 92.
    Sherwin, S. A., Twardzik, D. R., Bohn, W. H., Cockly, K. D. & Todaro, G. J. (1983) Cancer Res. 43, 403–407.PubMedGoogle Scholar
  94. 93.
    Gospodarowicz, D., Neufeld, G. & Schweigerer, L. (1986) Mol. Cell. Endocrinol. 46, 187–204.PubMedGoogle Scholar
  95. 94.
    Folkman, J. & Klagsbrun, M. (1987) Science 235, 442–447.PubMedGoogle Scholar
  96. 95.
    Ferrara, N., Schweigerer, L., Neufeld, G., Mitchell, R. & Gospodarowicz, D. (1987) Proc. Nat. Acad. Sci. USA 84, 5773–5777.PubMedGoogle Scholar
  97. 96.
    Moscatelli, D., Presta, M., Joseph-Silverstein, J. & Rifkin, D. B. (1986) J. Cell. Physiol. 129, 273–276.PubMedGoogle Scholar
  98. 97.
    Vlodavsky, I., Folkman, J., Sullivan, R., Friedman, R., Ishai-Michaeli, R., Sasse, J. & Klagsbrun, M. (1987) Proc. Natl Acad. Sci. USA 84, 2292–2296.PubMedGoogle Scholar
  99. 98.
    Winkles, J. A., Friesel, R., Burgess, W. H., Mehlman, T., Weinstein, R. & Maciag, T. (1987) Proc. Natl Acad. Sci. USA 84, 7124–7128.PubMedGoogle Scholar
  100. 99.
    Sato, Y. & Rifkin, D. B. (1988) J. Cell Biol. 107, 1199–1205.PubMedGoogle Scholar
  101. 100.
    Sakaguchi, M., Kajio, T., Kawahara, K. & Kato, K. (1988) FEBS Lett. 233, 163–166.PubMedGoogle Scholar
  102. 101.
    Klagsbrun, M., Sasse, J., Sullivan, R. & Smith, J. A. (1986) Proc. Natl Acad. Sci. USA 83, 2448–2452.PubMedGoogle Scholar
  103. 102.
    Schweigerer, L., Neufeld, G., Mergia, A., Abraham, J. A., Fiddes, J. C. & Gospodarowicz, D. (1987) Proc. Natl Acad. Sci. USA 84, 842–846.PubMedGoogle Scholar
  104. 103.
    Libermann, T.A., Friesel, R., Jaye, M., Lyall, R. M., Westermark, B., Drohan, W., Schmidt, A., Maciag, T. & Schlessinger, J. (1987) EM BO J. 6, 1627–1632.Google Scholar
  105. 104.
    Halaban, R., Kwon, B. S, Gkos, P., Delli Bovi, P. & Baird, A. (1988) Oncogene Res. 3, 177–186.PubMedGoogle Scholar
  106. 105.
    Ensoli, B., Nakamura, S., Salahuddin, S. Z., Biberfeld, P., Larsson, L., Beaver, B., Wong-Staal, F. & Gallo, R. C. (1989) Science 243, 223–226.PubMedGoogle Scholar
  107. 106.
    Jaye, M., Howk, R., Burgess, W., Ricca, G. A., Chiu, I.-M., Ravera, M. W., O’Brian, S. J., Modi, W. S., Maciag, T. & Drohan, W. N. (1986) Science 233, 541–545.PubMedGoogle Scholar
  108. 107.
    Abraham, J. A., Whang, J. L., Turnolo, A., Mergia, A., Friedman, J., Gospodarowicz, D. & Fiddes, J. C. (1986) EM BO J. 5, 2523–2528.Google Scholar
  109. 108.
    Rogelj, S., Weinberg, R. A., Fanning, P. & Klagsbrun, M. (1988) Nature 331, 173–175.PubMedGoogle Scholar
  110. 109.
    Sasada, R., Kurokawa, T., Iwane, M. & Igarashi, K. (1988) Mol. Cell. Biol. 8, 588–594.PubMedCentralPubMedGoogle Scholar
  111. 110.
    Neufeld, G., Mitchell, R., Ponte, P. & Gospodarowicz, D. (1988) J. Cell Biol. 106, 1385–1394.PubMedGoogle Scholar
  112. 111.
    Jaye, M., Lyall, R. M., Mudd, R., Schlessinger, J. & Sarver, N. (1988) EM BO J. 7, 963–969.Google Scholar
  113. 112.
    Moore, R., Casey, G., Brookes, S., Dixon, M., Peters, G. & Dickson, C. (1986) EM BO J. 5, 919–924.Google Scholar
  114. 113.
    Nusse, R. (1988) Trends Genet 4, 291–295.PubMedGoogle Scholar
  115. 114.
    Sakamoto, H., Mori, M., Taira, M., Yoshida, T., Matsukawa, S., Shimizu, K., Sekiguchi, M., Terada, M. & Sugimura, T. (1986) Proc. Natl Acad. Sci. USA 83, 3997–4001.PubMedGoogle Scholar
  116. 115.
    Taira, M., Yoshida, T., Miyagawa, K., Sakamoto, H., Terada, M. & Sugimura, T. (1987) Proc. Natl Acad. Sci. USA 84, 2980–2984.PubMedGoogle Scholar
  117. 116.
    Delli-Bovi, P., Curatola, A. M., Kern, F. G., Greco, A., Ittman, M. & Basilico, C. (1987) Cell 50, 729–737.PubMedGoogle Scholar
  118. 117.
    Delli-Bovi, P., Curatola, A. M., Newman, K. M., Sato, Y., Moscatelli, D., Hewick, R. M., Rifkin, D. & Basilico, C. (1988) Mol. Cell. Biol. 8, 2933–2941.PubMedCentralPubMedGoogle Scholar
  119. 118.
    Zhan, X., Culpepper, A., Reddy, M., Loveless, J. & Goldfarb, M. (1987) Oncogene 1, 369–376.PubMedGoogle Scholar
  120. 119.
    Zhan, X., Bates, B., Hu, X. & Goldfarb, M. (1988) Mol. Cell. Biol. 8, 3487–3495.PubMedCentralPubMedGoogle Scholar
  121. 120.
    Froesch, E. R., Schmid, C., Schwander, J. & Zapf, J. (1985) Annu. Rev. Physiol. 47, 443–467.PubMedGoogle Scholar
  122. 121.
    Yamada, Y. & Serrero, G. (1988) Proc. Natl Acad. Sci. USA 85, 5936–5940.PubMedGoogle Scholar
  123. 122.
    Minuto, F., Del Monte, P., Barreca, A., Alama, A., Cariola, G. & Giordano, G. (1988) Cancer Res. 48, 3716–3719.PubMedGoogle Scholar
  124. 123.
    Blatt, J., White, C., Dienes, S., Friedman, H. & Foley, T. (1984) Biochem. Biophys. Res. Commun. 123, 373–376.PubMedGoogle Scholar
  125. 124.
    Huff, K. K., Kaufman, D., Gabbay, K. H., Spencer, E. M., Lippman, M. E. & Dickson, R. B. (1986) Cancer Res. 46, 4613–4619.PubMedGoogle Scholar
  126. 125.
    Nissley, S. P., Short, P. A., Rechler, M. M., Podskalny, J. M. & Coon, H. (1978) Cell 11, 441–446.Google Scholar
  127. 126.
    Fu, X.-X., Su, C. Y., Lee, Y., Hintz, R., Biempica, L., Snyder, R. & Rogler, C. E. (1988) J. Virol. 62, 3422–3430.PubMedCentralPubMedGoogle Scholar
  128. 127.
    Reeve, A. E., Eccles, M. R., Wilkins, R. J., Bell, G. I. & Millow, L. J. (1985) Nature 317, 258–260.PubMedGoogle Scholar
  129. 128.
    Scott, J., Cowell, J., Robertson, M. E., Priestly, L. M., Wadey, R., Hopkins, B., Pritchard, J., Bell, G. I., Rall, L. N., Graham, C. F. & Knott, T. J. (1985) Nature 317, 260–262.PubMedGoogle Scholar
  130. 129.
    Höppener, J. W. M., Mosselman, S., Roholl, P. J. M., Lambrechts, C., Slebos, R. J. C., de Pagter-Holthuizen, P., Lips, C. J. M., Jansz, H. S. & Sussenbach, J. S. (1988) EM BO J. 7, 1379–1385.Google Scholar
  131. 130.
    Richmond, A., Lawson, D. H., Nixon, D. W., Stevens, J. S. & Chawla, R. K. (1982) Cancer Res. 42, 3175–3180.PubMedGoogle Scholar
  132. 131.
    Richmond, A., Fine, R., Murray, D., Lawson, D. H., & Priest, L. (1986) J. Invest. Dermatol. 86, 295–302.PubMedGoogle Scholar
  133. 132.
    Lawson, D. H., Thomas, H. G., Roy, R. G. B., Gordon, D. J., Chawla, R. K., Nixon, D. W. & Richmond, A. (1987) J. Cell. Biochem. 34, 169–185.PubMedGoogle Scholar
  134. 133.
    Richmond, A., Balentien, E., Thomas, H. G., Flaggs, G., Barton, D. E., Spiess, J., Brodini, R., Francke, U. & Derynck, R. (1988) EM BO J. 7, 2025–2033.Google Scholar
  135. 134.
    Anisowicz, A., Bardwell, L. & Sager, R. (1987) Proc. Natl Acad. Sci. USA 84, 7188–7192.PubMedGoogle Scholar
  136. 135.
    Castor, C. W., Miller, J. W. & Walz, D. A. (1983) Proc. Natl Acad. Sci. USA 80, 765–769.PubMedGoogle Scholar
  137. 136.
    Oquendo, P., Alberta, J., Wen, D., Graycar, J., Derynck, R. & Stiles C. D. (1989) J. Biol. Chem. 264, 4133–4137.PubMedGoogle Scholar
  138. 137.
    Kawahara, R. S. & Deuel, T. F. (1989) J. Biol. Chem. 264, 679–682.PubMedGoogle Scholar
  139. 138.
    Zacchary, I. & Rozengurt, E. (1985) Proc. Natl Acad. Sci. USA 82, 7616–7620.Google Scholar
  140. 139.
    Carney, D. N., Cuttitta, F., Moody, T. W. & Minna, J. D. (1987) Cancer Res. 47, 821–825.PubMedGoogle Scholar
  141. 140.
    Cuttitta, F., Carney, D. N., Mulshine, J., Moody, T. W., Fedorko, J., Fischler, A. & Minna, J. N. D. (1985) Nature 316, 823–826.PubMedGoogle Scholar
  142. 141.
    Layton, J. E., Scanlon, D. B., Soveny, C. & Morstyn, G. (1988) Cancer Res. 48, 4783–4789.PubMedGoogle Scholar
  143. 142.
    Metcalf, D. (1985) Science 229, 16–22.PubMedGoogle Scholar
  144. 143.
    Sachs, L. (1985) Science 238, 1374–1379.Google Scholar
  145. 144.
    Clark, S. C. & Kamen, R. (1987) Science 236, 1229–1237.PubMedGoogle Scholar
  146. 145.
    Jacobs, K., Shoemaker, C., Rudersdorf, R., Neill, S. D., Kaufman, R. J., Mufson, A., Seehra, J., Jones, S. S., Hewick, R., Fritsch, E. F., Kawakita, M., Shimizu, T. & Miyake, T. (1985) Nature 313, 806–809.PubMedGoogle Scholar
  147. 146.
    Young, D. & Griffin, J. D. (1986) Blood 68, 1178–1181.PubMedGoogle Scholar
  148. 147.
    Young, D., Wagner, K. & Griffin, J. D. (1987) J. Clin. Invest. 79, 100–106.PubMedCentralPubMedGoogle Scholar
  149. 148.
    Schrader, J. W. & Crapper, R. M. (1983) Proc. Natl Acad. Sci. USA. 80, 6892–6896.PubMedGoogle Scholar
  150. 149.
    Stocking, C., Löliger, C., Kawai, M., Sucin, S., Gough, N. & Ostertag, W. (1988) Cell 53, 869–879.PubMedGoogle Scholar
  151. 150.
    Baumbach, W. R., Colstone, E. M. & Cole, M. D. (1988) J. Virol. 9, 3151–3155.Google Scholar
  152. 151.
    Lang, R. A., Metcalf, D., Gough, N. M., Dunn, A. R. & Gonda, T.J. (1985) Cell 43, 531–542.PubMedGoogle Scholar
  153. 152.
    Laker, C., Stocking, C., Bergholz, U., Hess, N., De Lamarter, J. F. & Ostertag, W. (1987) Proc. Natl Acad. Sci. USA 84, 8458–8462.PubMedGoogle Scholar
  154. 153.
    Pierce, J. H., Di Fiore, P. P., Aaronson, S. A., Potter, M., Pumphrey, J., Scott, A. & Ihle, J. N. (1985) Cell 41, 685–693.PubMedGoogle Scholar
  155. 154.
    Cook, W. D., Metcalf, D., Nicola, N. A., Burgess, A. W. & Walker, F. (1985) Cell 41, 677–683.PubMedGoogle Scholar
  156. 155.
    O’Garra, A., Umland, S., De France, T. & Christiansen, J. (1988) Immunol. Today 9, 45–54.PubMedGoogle Scholar
  157. 156.
    Smith, K. A. (1988) Science 240, 1169–1176.PubMedGoogle Scholar
  158. 157.
    Taniguchi, T., Matsui, H., Fujita, Y., Hatakeymana, M., Kashima, N., Fuse, A., Hamuro, J., Hishi-Takaoka, C. & Yamada, G. (1986) Immunol. Rev. 92, 121–133.PubMedGoogle Scholar
  159. 158.
    Mingari, M. C., Gerosa, F., Carra, G., Accolla, R. S., Moretta, A., Zubler, R. H., Waldmann, T. A. & Moretta, L. (1984) Nature 312, 641–643.PubMedGoogle Scholar
  160. 159.
    Inoue, J., Seiki, M., Taniguchi, T., Tsuru, S. & Yoshida, M. (1986) EM BO J. 5, 2883–2888.Google Scholar
  161. 160.
    Maruyama, M., Shibuya, H., Harada, H., Hatakeyama, M., Seiki, M., Fujita, T., Inoue, J., Yoshida, M. & Taniguchi, T. (1987) Cell 48, 343–350.PubMedGoogle Scholar
  162. 161.
    Siekevitz, M., Feinberg, M. B., Holbrook, N., Wong-Staal, F. & Greene, W. C. (1987) Proc. Natl Acad. Sci. USA 84, 5389–5393.PubMedGoogle Scholar
  163. 162.
    Arya, S. L., Wong-Staal, F. & Gallo, R. C. (1984) Science 223, 1086–1087.PubMedGoogle Scholar
  164. 163.
    Duprez, V., Lenoir, G. & Dautry-Varsat, A. (1985) Proc. Natl Acad. Sci. USA 82, 6932–6936.PubMedGoogle Scholar
  165. 164.
    Arima, N., Daitoku, Y., Oghaki, S., Fukumori, J., Tanaka, H., Yamamoto, Y., Fujimoto, K. & Onoue, K. (1986) Blood 68, 779–782.PubMedGoogle Scholar
  166. 165.
    Dobbelaere, D. A. E., Coquerelle, T. M., Roditi, I. J., Eichhorn, M. & Williams, R. O. (1988) Proc. Natl Acad. Sci. USA 85, 4730–4734.PubMedGoogle Scholar
  167. 166.
    Lee, F., Yokota, T., Otsuka, T., Meyerson, P., Villaret, D., Coffman, R., Mosmann, T., Rennick, D., Roehm, N., Smith, C., Zlotnik, A. & Arai, K. (1986) Proc. Natl Acad. Sci. USA 83, 2061–2065.PubMedGoogle Scholar
  168. 167.
    Noma, Y., Sideras, P., Naito, T., Bergstedt-Lindquist, S., Azuma, C., Severinson, E., Tanabe, T., Kinashi, T., Matsuda, F., Yaoita, Y. & Honjo, T. (1986) Nature 319, 640–646.PubMedGoogle Scholar
  169. 168.
    Ohara, J. & Paul, W. E. (1987) Nature 325, 537–540.PubMedGoogle Scholar
  170. 169.
    Fernandez-Botran, R., Sanders, V. M., Olivier, K. G., Chen, Y. M., Krammer, P. H., Uhr, J. W. & Vitetta, E. S. (1986) Proc. Natl Acad. Sci. USA 83, 9689–9693.PubMedGoogle Scholar
  171. 170.
    Lichtman, A. H., Kurt-Jones, E. A. & Abbas, A. K. (1987) Proc. Natl Acad. Sci. USA 84, 824–827.PubMedGoogle Scholar
  172. 171.
    Brown, M. A., Pierce, J. H., Watson, C. J., Falco, J., Ihle, J. N. & Paul, W. E. (1987) Cell 50, 809–818.PubMedGoogle Scholar
  173. 172.
    Haegeman, G., Content, J., Volckaert, G., Derynck, R., Tavernier, J. & Fiers, W. (1986) Eur. J. Biochem. 159, 625–632.PubMedGoogle Scholar
  174. 173.
    May, L. T., Helgott, D. C. & Sehgal, P. B. (1986) Proc. Natl Acad. Sci. USA 83, 8957–8961.PubMedGoogle Scholar
  175. 174.
    Zilberstein, A., Ruggieri, R., Korn, J. H. & Revel, M. (1986) EM BO J. 5, 2529–2537.Google Scholar
  176. 175.
    Van Snick, J., Cayphas, S., Vink, A., Uyttenhove, C., Coulie, P. G., Rubira, M. R. & Simpson, R. J. (1986) Proc. Natl Acad. Sci. USA 83, 9679–9683.PubMedGoogle Scholar
  177. 176.
    Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T. & Kishimoto, T. (1986) Nature 324, 73–76.PubMedGoogle Scholar
  178. 177.
    . Kohase, M., Henriksen-DeStefano, D., May, L. T., Vilcek, J. & Sehgal, P. B. (1986) Cell 45, 659–666.PubMedGoogle Scholar
  179. 178.
    Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., Kuramoto, A. & Kishimoto, T. (1988) Nature 332, 83–85.PubMedGoogle Scholar
  180. 179.
    Gordon, J., Ley, S. C., Melamed, M. D., English, L. S. & Hughes-Jones, N. C. (1984) Nature 310, 145–147.PubMedGoogle Scholar
  181. 180.
    Porter, S., Glaser, L. & Bunge, R. P. (1987) Proc. Natl Acad. Sci. USA 84, 7768–7772.PubMedGoogle Scholar
  182. 181.
    Sato, Y. & Rifkin, D. B. (1988) J. Cell Biol. 107, 1199–1205.PubMedGoogle Scholar
  183. 182.
    Seifert, R. A., Schwartz, S. M. & Bowen-Pope, D. F. (1984) Nature 311, 669–671.PubMedGoogle Scholar
  184. 183.
    Nilsson, J., Sjölund, M., Palmberg, L., Thyberg, J. & Heldin, C.-H. (1985) Proc. Natl Acad. Sci. USA 82, 4418–4422.PubMedGoogle Scholar
  185. 184.
    Sejersen, T., Betsholtz, C., Sjölund, M., Heldin, C.-H., Westermark, B. & Thyberg, J. (1986) Proc. Natl Acad. Sci. USA 83, 6844–6848.PubMedGoogle Scholar
  186. 185.
    Goustin, A. S., Betsholtz, C., Pfeifer-Ohlsson, S., Persson, H., Rydnert, J., Bywater, M., Holmgren, G., Heldin, C.-H., Westermark, B. & Ohlsson, R. (1985) Cell 41, 301–312.PubMedGoogle Scholar
  187. 186.
    Paulsson, Y., Hammacher, A., Heldin, C.-H. & Westermark, B. (1987) Nature 318, 715–717.Google Scholar
  188. 187.
    Coffey, R. J. Jr, Derynck, R., Wilcox, J. N., Bringman, T. S., Goustin, A. S., Moses, H. L. & Pittelkow, M. R. (1987) Nature 328, 817–820.PubMedGoogle Scholar
  189. 188.
    van Obbergen-Schilling, E., Roche, N. S., Flanders, K. C., Sporn, M. B. & Roberts, A. B. (1988) J. Biol. Chem. 263, 7741–7746.Google Scholar
  190. 189.
    Dinarello, C. A., Ikejima, T., Warner, S. J. C., Oreucole, S. F., Lonnemann, G., Cannon, J. G., & Libby, P. (1987) J. Immunol. 139, 1902–1910.PubMedGoogle Scholar
  191. 190.
    Ymer, S., Tucker, W. Q. J., Sanderson, C. J., Hapel, A. J., Campbell, H. D. & Young, I. G. (1985) Nature 317, 255–258.PubMedGoogle Scholar
  192. 191.
    Chen, S. J., Holbrook, N. J., Mitchell, K. F., Vallone, C. A., Freegard, J. S., Crabtree, G. R. & Lin, Y. (1985) Proc. Natl Acad. Sci. USA 82, 7284–7288.PubMedGoogle Scholar
  193. 192.
    Adkins, B., Lautz, A. & Graf, T. (1984) Cell 39, 439–445.PubMedGoogle Scholar
  194. 193.
    Graf, T., von Weizsäcker, F., Grieser, S., Coll, J., Stehelin, D., Patschinsky, T., Bister, K., Bechade, C., Calothy, G. & Leutz, A. (1986) Cell 45, 357–364.PubMedGoogle Scholar
  195. 194.
    von Weizsäcker, F., Beug, H. & Graf, T. (1986) EM BO J. 5, 1521–1528.Google Scholar
  196. 195.
    Yoshida, M. C., Wada, M., Satoh, H., Yoshida, T., Sakamoto, H., Miyagawa, K., Yokota, J., Koda, T., Kakinuma, M., Sugimura, T. & Terada, M. (1988) Proc. Natl Acad. Sci. USA 85, 4861–4864.PubMedGoogle Scholar
  197. 196.
    Ali, I. U., Merlo, G., Callahan, R. & Liderau, R. (1989) Oncogene, 4, 89–92.PubMedGoogle Scholar
  198. 197.
    Browder, T. M., Abrams, J. S., Wong, P. M. C. & Nienhuis, A. W. (1989) Mol. Cell. Biol. 9, 204–213.PubMedCentralPubMedGoogle Scholar
  199. 198.
    Betsholtz, C., Westermark, B., Ek, B. & Heldin, C.-H. (1984) Cell 39, 447–457.PubMedGoogle Scholar
  200. 199.
    Keating, M. T. & Williams, L. T. (1988) Science 239, 914–916.PubMedGoogle Scholar
  201. 200.
    Huang, S. S. & Huang, J. S. (1988) J. Biol. Chem. 263, 12608–12618.PubMedGoogle Scholar
  202. 201.
    Hannink, M. & Donoghue, D. J. (1988) J. Cell Biol. 107, 287–298.PubMedGoogle Scholar
  203. 202.
    Kahn, P., Frykberg, L., Brady, C., Stanly, I., Beug, H., Vennström, B. & Graf, T. (1986) Cell 45, 349–356.PubMedGoogle Scholar
  204. 203.
    Deinhardt, F. (1980) in Viral oncology (Klein, G., ed.) pp. 359–398, Raven Press, New York.Google Scholar
  205. 204.
    Greene, W., Leonard, W., Wano, Y., Svetlik, P., Pfeffer, N., Sodorski, J., Rosen, C. A., Goh, W. C. & Haseltine, W. A. (1986) Science 232, 877–880.PubMedGoogle Scholar
  206. 205.
    Sporn, M. B. & Roberts, A. B., eds (1989) Peptide growth factors and their receptors, Handbook of Experimental Pharmacology, Springer Verlag, Heidelberg, in the press.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Carl-Henrik Heldin
    • 1
  • Bengt Westermark
    • 2
  1. 1.Ludwig Institute for Cancer ResearchBiomedical CenterUppsalaSweden
  2. 2.Department of PathologyUniversity HospitalUppsalaSweden

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