Cellular and Molecular Basis of the Protective Immune Response to Cytomegalovirus Infection
Cytomegalovirus (CMV) infection can occur throughout life. Similar to other herpesviruses, after primary infection CMV remains in the host in a latent state. Infection of the immunocompetent host does not cause clinical symptoms, whereas infection of the immunocompromised host can cause severe and even fatal disease. Morbidity and mortality associated with primary CMV infection or with reactivation from latency is common in immunosuppressed transplant recipients and in patients with immunodeficiency caused by HIV infection. CMV pneumonia is considered the immediate cause of death in these patients.
KeywordsMajor Histocompatibility Complex Major Histocompatibility Complex Class Cytomegalovirus Infection Protective Immune Response Salivary Gland Tissue
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- Borysiewicz LK, Hickling JK, Graham S, Sinclair J, Cranage MP, Smith GL, Sissons JGP (1988) Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage specific CTL recognizing the 72 kD immediate early protein and glycoprotein B expressed by recombinant vaccinia virus. J Exp Med 168:919–932.PubMedCrossRefGoogle Scholar
- Eizura Y, Minamishima Y (1979) Co-variation of pathogenicity and antigenicity in murine cytomegalovirus. Microbiol Immunol 23: 559–564.Google Scholar
- Emanuel D, Cunningham I, Jules-Elysee K, Brochstein JA, Kernan NA, Laver J, Stover D, et al. (1988) Cytomegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high-dose intravenous immune globulin. Ann Intern Med 109: 777–782.PubMedGoogle Scholar
- Quinnan GV, Kirmani N, Rook AH, Manischewitz J, Jackson L, Moreschi G, Santos GW, et al. (1982) HLA-restricted T-lymphocyte and non T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N Engl J Med 307: 7–13.PubMedCrossRefGoogle Scholar
- Reddehase MJ, Keil GM, Koszinowski UH (1984a) The cytolytic T lymphocyte response to the murine cytomegalovirus. I. Distinct maturation stages of cytolytic T lymphocytes constitute the cellular immune response during acute infection of mice with the murine cytomegalovirus. J Immunol 132:482–489.PubMedGoogle Scholar
- Reddehase MJ, Keil GM, Koszinowski UH (1984b) The cytolytic T lymphocyte response to the murine cytomegalovirus. II. Detection of virus replication stage-specific antigens by separate populations of in vivo active cytolytic T lymphocyte precursors. Eur J Immunol 14: 56–61.PubMedCrossRefGoogle Scholar
- Reddehase MJ, Jonjić S, Weiland F, Mutter W, Koszinowski UH (1988) Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors. J Virol 62: 1061–1065.PubMedGoogle Scholar
- Zinkernagel RM, Doherty PC (1979) MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol 27: 52–177.Google Scholar