Clinical Studies with Budotitane — A New Non-Platinum Metal Complex for Cancer Therapy
Conference paper
Abstract
The new antitumor-active transition metal complex diethoxybis(1-phenylbutane-1,3-dionato)tita- nium(IV) (INN Budotitane, DBT) has demonstrated antitumor activity in several experimental tumor models. The cytotoxic activity of DBT in the AMMN-induced autochthonous colorectal carcinoma in the rat appeared especially promising. In the preclinical toxicity studies, liver toxicity, mild nephrotoxicity, but no myelosuppression was observed.
Keywords
Dose Level Titanium Concentration Experimental Tumor Model Gallium Nitrate Reversible Impairment
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