Immunological Analysis of Mycobacterial Disease

  • J. Ivanyi
Conference paper

Abstract

One night Milan unexpectedly called at our flat in central Prague in an elated mood and asked for a cup of strong, black coffee. However, before coffee was prepared, he dozed off on the sofa. After a while, we opted to make him comfortable with a pillow and blanket and went to bed. In the middle of the night we were woken by the weight of Milan’s body diagonally across us on the bed. Milan, while asleep, resisted all our efforts to move him into a parallel position in the middle of the bed. Defeated, we retreated next door and went to sleep on the floor. In the morning, amazed by the situation, Milan disappeared and soon returned with an enormous bouquet of flowers for my wife Lida.

Keywords

Mycobacterium Bovis Immunological Analysis Lepromatous Leprosy Mycobacterial Disease Tuberculoid Leprosy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bloom BR, Mehra V (1984) Immunological unresponsiveness in leprosy. Immunol Rev 80: 5PubMedCrossRefGoogle Scholar
  2. Bothamley GH, Udani PM, Rudd R, Festenstein F, Ivanyi J (1988) Antibody levels in smear positive and smear negative thoracic tuberculosis of adults and children. Eur J Clin Microbiol Inf 7:639CrossRefGoogle Scholar
  3. Bothamley GH, Beck J, Schreuder G, D’Amaro J, de Vries RRP, Kardjito T, Ivanyi J (1989) HLA-DR2 and DQwl association with tuberculosis and antibody levels to the 38kDa antigen. J Inf Dis 159: 549–555CrossRefGoogle Scholar
  4. Cox JH, Ivanyi J (1988) The role of host factors for the chemotherapy of BCG infection in inbred strains of mice. Acta Pathol Microbiol Immunol Scand 96: 927CrossRefGoogle Scholar
  5. Cox JH, Ivanyi J, Young DB, Lamb JR, Syred AD, Francis M (1989) Orientation of epitopes influences the immunogenicity of synthetic peptide dimers. Eur J Immunol (in press)Google Scholar
  6. Hart P D’arcy, Rees RJW (1950) Enhancing effect of cortisone on tuberculosis in the mouse. Lancet 2:391CrossRefGoogle Scholar
  7. Ivanyi J (1986) Pathogenic and protective interactions in mycobacterial infections. Clin Immunol Allergy 60: 127–157Google Scholar
  8. Ivanyi J, Bothamley GH, Jackett PS (1988 a) Immunodiagnostic assays for tuberculosis and leprosy. Br Med Bull 44: 635–649PubMedGoogle Scholar
  9. Ivanyi J, Sharp K, Jackett P, Bothamley G (1988 b) Immunological study of the defined constituents of mycobacteria. Springer Semin Immunopathol 10: 279PubMedCrossRefGoogle Scholar
  10. Jackett P, Bothamley G, Batra HV, Mistry A, Young DB, Ivanyi J (1988) Epitope and whole antigen molecule specificities in the serology of tuberculosis. J Clin Microbiol 26: 2313PubMedGoogle Scholar
  11. Kaufmann SHE (1988) CD8+ T lymphocytes in intracellular microbial infections. Immunol Today 9: 168–174PubMedCrossRefGoogle Scholar
  12. Lamb JR, Ivanyi J, Rees ADM, Rothbard JB, Howland K, Young RA, Young DB (1987) Mapping of T cell epitopes using recombinant antigens and synthetic peptides. EMBO J 6: 1245PubMedGoogle Scholar
  13. Lovik M, Closs O (1982) Repeated delayed-type hypersensitivity reactions against Mycobacterium lepraemurium antigens at the infection site do not affect bacillary multiplication in C3H mice. Infect Immun 36: 768PubMedGoogle Scholar
  14. Mendez-Samperio P, Lamb J, Bothamley G, Stanley P, Ellis C, Ivanyi J (1989) Molecular study of the T cell repertoire in family contacts and patients with leprosy. J Immunol (In press)Google Scholar
  15. Modlin RL, Rea TH (1988) Immunopathology of leprosy granulomas. Springer Semin Immunopathol 10: 359PubMedCrossRefGoogle Scholar
  16. Moreno C, Angela M, Lamb J (1988) The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation. Clin Exp Immunol 74: 206PubMedGoogle Scholar
  17. Mustafa AS, Kvalheim G, Degré M, Godai T (1986) Mycobacterium bovis BCG-induced human T cell clones from BCG-vaccinated healthy subjects: antigen specificity and lymphokine production. Infect Immun 53: 491PubMedGoogle Scholar
  18. Nogueira N, Kaplan G, Levy E et al. (1983) Defective gamma interferon production in leprosy: reversal with antigen and IL-2. J Exp Med 158: 2165–2170PubMedCrossRefGoogle Scholar
  19. Prasad HK, Mishra RS, Nath I (1987) Phenolic glycolipid-I of Mycobacterium leprae induces general suppression of in vitro concanavalin a responses unrelated to leprosy type. J Exp Med 165: 239PubMedCrossRefGoogle Scholar
  20. Rook GAW, Carswell JW, Stanford JL (1976) Preliminary evidence for the trapping of antigen-specific lymphocytes in the lymphoid tissu of “anergic” tuberculosis patients. Clin Exp Immunol 16:129–132Google Scholar
  21. Sengupta U, Sinha S, Ramu G, Lamb J, Ivanyi J (1987) Suppression of delayed hypersensitivity skin reactions to tuberculin by M. lepare antigens in patients with lepromatous and tuberculoid leprosy. Clin Exp Immunol 68: 58PubMedGoogle Scholar
  22. Young DB, Lathigra R, Hendrix R, Sweetser D, Young RA (1988) Stress proteins are immune targets in leprosy and tuberculosis. Proc Natl Acad Sci USA 85: 4267–4270PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Ivanyi

There are no affiliations available

Personalised recommendations