Sequential Decision Strategy of the AML Cooperative Group Studies

  • A. Heinecke
  • M. C. Sauerland
  • T. Büchner
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

The purpose of this poster is to show that sequential procedures are appropriate for clinical studies with prolonged observations. We present the sequential log-rank test used by the German AML Cooperative Group in its randomized studies.

Keywords

Acute Myeloid Leukemia Federal Republic Clinical Center Sequential Procedure Terminal Event 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Büchner T, Urbanitz D, Hiddemann W (1985) Intensified induction and consolidation with or without maintenance, chemotherapy for acute myeloid leukemia (AML): two multicenter studies of the German AML Cooperative Group. J Clin Oncol 3: 1583–1589PubMedGoogle Scholar
  2. 2.
    Whitehead J (1983) The design and analysis of sequential clinical trials. Horwood, ChichesterGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • A. Heinecke
    • 1
  • M. C. Sauerland
    • 1
  • T. Büchner
    • 2
  1. 1.Department of Medical BiostatisticsUniversity of MünsterGermany
  2. 2.Department of Internal Medicine, Hematology/OncologyUniversity of MünsterGermany

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