Cloning of the Breakpoint Junction of the Translocation 14;19 in Chronic Lymphocytic Leukemia

  • T. McKeithan
  • H. Ohno
  • J. Rowley
  • M. Diaz
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Human B-cell lymphocytic neoplasms are often associated with specific cytogenetic abnormalities that correlate with their histological and immunologic phenotypes. The genes located at the breakpoints of these recurring chromosomal translocations appear to be integrally involved in the pathogenesis of the corresponding B-cell neoplasms. Our laboratory has recently reported that t(14;19) (q32;ql3.1) is a recurring translocation in chronic lymphocytic leukemia (CLL). We have analyzed the leukemic cells from two such patients in detail using various probes from the very complex immunoglobulin heavy chain locus (IGH). In both cases, the t(14;19) was part of a three-way translocation with loss of the derivative chromosome containing the q terminus of the affected chromosome 14.

Keywords

Chronic Lymphocytic Leukemia Somatic Cell Hybrid Immunoglobulin Heavy Chain Switch Region Derivative Chromosome 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. McKeithan
    • 1
    • 2
  • H. Ohno
    • 1
    • 2
  • J. Rowley
    • 1
    • 2
  • M. Diaz
    • 1
    • 2
  1. 1.Deparatment of PathologyUniversity of ChicagoChicagoUSA
  2. 2.Deparatment of MedicineUniversity of ChicagoChicagoUSA

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