Antiandrogens: Clinical Aspects

  • J. Hammerstein


For a long time, the only means for combatting hirsutism were ablative surgery, the mechanical removal of body hair such as through shaving, plucking, waxing, chemical depilation and electrolysis, or simply bleaching. When glucocorticoids became available in the early 1950s, it was hoped that adrenal hirsutism and virilism could be treated by the suppressive action of these hormonal compounds upon adrenal androgen hypersecretion via a reduction in the release of pituitary ACTH. In fact, this was shown by Wilkins et al. (1950) to be true in the case of congenital adrenal hyperplasia (originally, congenital, adrenogenital syndrome). Since that time the use of glucocorticoids has become the method of choice for this type of inborn enzymatic disturbance.


Congenital Adrenal Hyperplasia Cyproterone Acetate Androgenetic Alopecia Sebum Production Hirsute Woman 
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© Springer-Verlag Berlin Heidelberg 1990

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  • J. Hammerstein

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