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Brown Adipose Tissue, Diet-Induced Thermogenesis and Genetic Obesity

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Molecular Basis of Membrane-Associated Diseases
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Abstract

Brown adipose tissue is a thermogenic organ that effectively participates in the maintenance of body temperature in newborn mammals and in adult hibernating animals. The high triglycéride content of brown adipose tissue cells, the high oxidative capacity and specific mitochondrial proton channel which enables energy dissipation in the form of heat are involved in the protection of the animal body against cold (Lindberg 1970; Jänský 1973; Nichols 1979; Cannon and Needergard 1985).

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References

  • Bazin R, Eteve D, Lavau M (1984) Evidence for decreased GDP binding to brown adipose tissue mitochondria of obese Zucker fa/fa rats in the very first days of life. Biochem J 221:241–245

    PubMed  CAS  Google Scholar 

  • Cannon B, Nedergaard J (1985) Brown adipose tissue: molecular mechanisms controlling activity and thermogenesis. In: Cryer A,.Van RLR(eds) New perspectives in adipose tissue: structure, function and development. Butterworths, London, pp 223–270

    Google Scholar 

  • Drahota Z, Svoboda P, Soukup T, Rauchovä H, Dosoudilovä J, Vitek V, Kotyk A (1987) Structural and functional alterations of brown adipose tissue in animals with hereditary induced obesity. Proc Symp Membr Diss, Bari

    Google Scholar 

  • Goodbody AE, Trayhurn P (1981) GDP binding to brown adipose mitochondria of diabetic-obese db/db mice. Decreased binding in both the obese and pre-obese states. Biochem J 194:1019–1022

    PubMed  CAS  Google Scholar 

  • Goodbody AE, Trayhurn P (1982) Studies on the activity of brown adipose tissue in suckling, pre-obese, ob/ob mice. Biochem Biophys Acta680:119–126

    Article  PubMed  CAS  Google Scholar 

  • Himms-Hagen J (1983) Role of thermogenesis in brown adipose tissue. In: Angel A, Hollenberg CH, Roncari DAK (eds) The regulation of energy balance in the adipocyte and obesity: cellular and molecular mechanisms. Raven, New York, pp 259–270 264

    Google Scholar 

  • Himms-Hagen J (1984) Brown adipose tissue thermogenesis, energy balance and obesity. Can J Biochem Cell Biol 62:610–617

    Article  PubMed  CAS  Google Scholar 

  • Hromadovä M, Palkovic M, Skottovä N (1980) Plasma lipoproteins and activities of several enzymes involved in the lipid metabolism in spontaneously obese rats. In: Palkovic M (ed) Advances in Physiological Science vol 35. Hormones, lipoproteins and atherosclerosis. Akad Kiadó, Budapest, pp 347–360

    Google Scholar 

  • Jänský L (1973) Non-shivering thermogenesis and its thermoregulatory significance. Biol Rev 43:85–132

    Google Scholar 

  • Jezek P, Houštěk J, Kotyk A, Drahota Z (1988) Distinct affinity and effector residues in the binding site for a regulatory ligand. Eur Biophys J 16:101–108

    Article  PubMed  CAS  Google Scholar 

  • Koletski S (1973) Obese spontaneously hypertensive rats — a model for study of atherosclerosis. Exp Mol Pathol 19:53–60

    Article  Google Scholar 

  • Kopecky J, Jezek P, Drahota Z, Houštěk J (1987) Control of uncoupling protein in brown fat mitochondria by purine nucleotides. Chemical modification by diazobenzenesulfonate. Eur J Biochem 164:687–694

    Article  PubMed  CAS  Google Scholar 

  • Lindberg O (ed) (1970) Brown adipose tissue. Elsevier, Amsterdam New York

    Google Scholar 

  • Lonĝar D, Bedrica L, Mayer J, Cannon B, Nedergaard J, Afzelius BA, Svajger A (1986) The effect of intermittent cold treatment on the adipose tissue of the cat. J Ultrastruct Mol Struct Res 97:119–129

    Article  Google Scholar 

  • Nichols DG (1979) Brown adipose tissue mitochondria. Biochim Biophys Acta 549:1–29

    Google Scholar 

  • NIH Rodents Catalogue, NIH Publication (1981) N08I-606, Bethesda:253

    Google Scholar 

  • Rothwell NJ, Stock MJ (1979) A role for brown adipose tissue in diet induced thermogenesis. Nature (London) 281:31–35

    Article  CAS  Google Scholar 

  • Sclafani A (1984) Animal models of obesity: classification and characterization. Int J Obes 8:491–508

    PubMed  CAS  Google Scholar 

  • Trayhurn P, Mercer SW (1986) Brown adipose tissue in obese animals. Biochem Soc Trans 14:236–239

    PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Soukup, T., Rauchová, H., Dosoudilová, J., Drahota, Z. (1989). Brown Adipose Tissue, Diet-Induced Thermogenesis and Genetic Obesity. In: Azzi, A., Drahota, Z., Papa, S. (eds) Molecular Basis of Membrane-Associated Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74415-0_22

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  • DOI: https://doi.org/10.1007/978-3-642-74415-0_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74417-4

  • Online ISBN: 978-3-642-74415-0

  • eBook Packages: Springer Book Archive

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