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No Effect on ICP of ACE-Inhibition During Induced Hypotension

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Intracranial Pressure VII

Abstract

Experimental studies in rats have demonstrated that the angiotensin converting enzyme (ACE) inhibitor Captopril shifts the lower and upper limits of autoregulation of cerebral blood flow (CBF) towards lower blood pressure levels (Barry et al. 1984). Studies in patients with severe cardiac failure, hypertension and normal volunteers suggest a similar effect in man (Paulson et al. 1988). The present study was undertaken in order to further evaluate the effect of Captopril on cerebral autoregulation, the intracranial pressure (ICP) and the cerebral perfusion pressure.

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References

  • Barry DI, Jarden JO, Paulson OB, Graham DI, Strandgaard S (1984) Cerebrovascular aspects of converting enzyme inhibition. I. Effects of intravenous captopril in spontaneously hypertensive and normotensive rats. J Hypertens 2: 589–597

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  • Strandgaard S, Paulson OB (1984) Cerebral autoregulation. Stroke 15: 413–416

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Author information

Authors and Affiliations

  1. Department of Neurosurgery and Neurology, Rigshospitalet, University of Copenhagen, DK-2100, Copenhagen, Denmark

    J. F. Schmidt, A. R. Andersen, F. Gjerris & O. B. Paulson

Authors
  1. J. F. Schmidt
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  2. A. R. Andersen
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  3. F. Gjerris
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  4. O. B. Paulson
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Editor information

Editors and Affiliations

  1. Section of Neurosurgery, University of Michigan Hospitals, 1500 E. Medical Center Dr., 48109-0338, Ann Arbor, MI, USA

    Julian T. Hoff MD (Professor of Surgery, Chief) (Professor of Surgery, Chief)

  2. Crosby Laboratories, Section of Neurosurgery, University of Michigan Hospitals, 1500 E. Medical Center Dr., 48109-0338, Ann Arbor, MI, USA

    A. Lorris Betz MD, PhD (Professor of Pediatrics, Neurology, and Surgery, Director) (Professor of Pediatrics, Neurology, and Surgery, Director)

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© 1989 Springer-Verlag Berlin Heidelberg

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Schmidt, J.F., Andersen, A.R., Gjerris, F., Paulson, O.B. (1989). No Effect on ICP of ACE-Inhibition During Induced Hypotension. In: Hoff, J.T., Betz, A.L. (eds) Intracranial Pressure VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73987-3_140

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  • DOI: https://doi.org/10.1007/978-3-642-73987-3_140

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73989-7

  • Online ISBN: 978-3-642-73987-3

  • eBook Packages: Springer Book Archive

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