Cucurbita moschata Duch.

  • Weici Tang
  • Gerhard Eisenbrand


The seeds of Cucurbita moschata Duch. (Cucurbitaceae) were used originally in traditional Chinese medicine as an ascaricidal agent for treatment of human ascari-asis. It was then found to be active in inhibiting the growth of immature Schistosoma japonicum and was used clinically for treatment of schistosomiasis. It is not officially listed in the Chinese Pharmacopoeia.


Schistosoma Japonicum Chinese Pharmacopoeia Human Ascari Cucurbita Species Cucurbita Moschata 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Fang ST, Li LC, Niu CI, Tseng KF (1961) Chemical studies on Cucurbita moschata. I. The isolation and structural studies of cucurbitin, a new amino acid. Sci Sin 10:845–851PubMedGoogle Scholar
  2. 2.
    Fan HF, Lin CC (1965) The crystal structure of cucurbitin Perchlorate and the absolute configuration of the cucurbitin molecule. Acta Phys Sin 21:253–262Google Scholar
  3. 3.
    Gonzalez AE, Bravo OR, Garcia MH, Santos RM de la, Tomas ML del (1974) Pharmacological (anthelmintic) study of Cucurbita maxima seeds and their active principle, cucurbitin. An R Acad Farm 40:47–86Google Scholar
  4. 4.
    Shiao SH, Shao BJ, Ho YH, Yang YC, Mao CP (1962) Prophylactic therapeutic effect of cucurbitin in experimental schistosomiasis in mice. Sci Sin 11:1527–1534PubMedGoogle Scholar
  5. 5.
    Hsiao SH, Hsu YC (1965) The effect of some schistosomacides on glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase of Schistosoma japonicum. Acta Pharm Sin 12:242–248Google Scholar
  6. 6.
    Tao IH, Huang TY (1964) Arginase of Schistosoma japonicum. Acta Biochim Biophys Sin 4:161–166Google Scholar
  7. 7.
    Liang Y, Marlowe C, Waddell WJ (1982) Autoradiographic study on tissue localization of (C-14)cucurbitin in mice. Acta Pharmacol Sin 3:267–269Google Scholar
  8. 8.
    Misranian VH, Abou-Chaar CI (1968) Extraction, detection and estimation of cucurbitin in Cucurbita seeds. Lloydia 31:23–29Google Scholar
  9. 9.
    Sun CJ, Ji RY (1985) Synthesis of some cucurbitin derivatives and related compounds. Acta Pharm Sin 20:214–218Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

Personalised recommendations