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Immunotherapy of Pancreatic Cancer with Monoclonal Antibody BW 494: Results from a Multicentric Phase I–II Trial

  • Conference paper
Cancer Therapy

Abstract

In this age of modern diagnostic procedures and highly developed conservative and surgical therapeutic strategies in oncology, pancreatic carcinoma of ductal origin is still almost invariably an incurable disease [1, 2]. A characteristic tumor biology with regard to growth behavior, metastatic mode, and unspecific symptoms in the initial stage are responsible for this poor prognosis [3–5]. The incurability of pancreatic cancer is duly emphasized by the evaluation of data collected from 15 000 patients. These statistics show that after 5 years, independent of the type of therapy, a total of 60 patients (0.4% with 5-year survival) were still alive [2]. Only about 10%–20% of the patients are able to undergo a potentially curative operation in the form of a partial or total pancreatoduodenectomy [1, 2, 6–9]. The therapeutic dilemma is further characterized by the lack of response to chemo- or radiotherapy [10–15].

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Author information

Authors and Affiliations

  1. Department of General Surgery, University of Ulm, Steinhövelstraße 9, 7900, Ulm, Germany

    M. Büchler, R. Kübel, H. Friess, B. Lorenz & H. G. Beger

  2. Department of Internal Medicine, University Hospital Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    R. Klapdor

  3. Department of General and Thoracic Surgery, Justus Liebig University Clinic, Klinikstraße 29, 6300, Gießen, Germany

    K.-H. Muhrer

  4. Clinical Research, Behringwerke AG Marburg, 3550, Marburg, Germany

    G. Schulz & K. Bosslet

Authors
  1. M. Büchler
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  2. R. Kübel
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  3. R. Klapdor
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  4. K.-H. Muhrer
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  5. H. Friess
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  6. B. Lorenz
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  7. G. Schulz
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  8. K. Bosslet
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  9. H. G. Beger
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Editor information

Editors and Affiliations

  1. Department of General Surgery, University of Ulm, Steinhövelstraße 9, 7900, Ulm, Germany

    Hans G. Beger FACS (Professor of Surgery) & Markus Büchler (Lecturer in Surgery) (Professor of Surgery) &  (Lecturer in Surgery)

  2. Division of Tumor Cell Biology, Scripps Clinic & Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Ralph A. Reisfeld

  3. Clinical Research, Behringwerke AG Marburg, P.O. Box 1140, 3550, Marburg, Germany

    Gregor Schulz

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© 1989 Springer-Verlag Berlin · Heidelberg

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Büchler, M. et al. (1989). Immunotherapy of Pancreatic Cancer with Monoclonal Antibody BW 494: Results from a Multicentric Phase I–II Trial. In: Beger, H.G., Büchler, M., Reisfeld, R.A., Schulz, G. (eds) Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73721-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-73721-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73723-7

  • Online ISBN: 978-3-642-73721-3

  • eBook Packages: Springer Book Archive

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