A Murine Model for Coxsackievirus B3-Induced Acute Myocardial Necrosis for Study of Cellular Receptors as Determinants of Viral Tropism

  • R. L. Crowell
  • S. D. Finkelstein
  • K.-H. L. Hsu
  • B. J. Landau
  • P. Stalhandske
  • P. S. Whittier
Conference paper


A number of studies have contributed to the working hypothesis that specific cellular receptors, if present in sufficient quantity, serve as major determinants of both the host range and tissue tropism in the pathogenesis of human and animal picornavirus infections [14, 21, 28, 36, 42]. Though picornaviruses contain relatively small genomes, they produce a bewildering array of diseases. It is likely that one of the several factors contributing to disease diversity is due to the specific requirement of individual viruses for host cell receptors, For example, we have postulated [12a] that genetic changes in the virion attachment site could occur during virus replication in infected individuals, These changes could influence the course of the disease [9, 23, 51] by altering the virus receptor specificity, This would be of special importance if different receptors occurred on different tissues.


HeLa Cell Cellular Receptor Mouse Hepatitis Virus Rhabdomyosarcoma Cell Straight Arrow 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • R. L. Crowell
    • 1
  • S. D. Finkelstein
    • 2
  • K.-H. L. Hsu
    • 1
  • B. J. Landau
    • 1
  • P. Stalhandske
    • 1
  • P. S. Whittier
    • 1
  1. 1.Department of Microbiology and ImmunologyHahnemann University School of Medicine Broad and VinePhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineHahnemann University School of Medicine Broad and VinePhiladelphiaUSA

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