The Effect of DNA Methylation on DNA-Protein Interactions and on the Regulation of Gene Expression

  • Walter Doerfler
Chapter

Abstract

The transcriptional activity of a gene can be controlled in a number of ways and modulated by different factors. The interaction of specific proteins with highly specific sequence elements (“motifs”) in the promoter regions of genes plays a pivotal role in this regulation (see Schlokat and Gruss, this Vol., and Beato, this Vol.). In addition, the methylation of promoter sequences can cause the inactivation of genes in a number of eukaryotic systems (for reviews see Razin and Riggs 1980; Doerfler 1981, 1983; Riggs and Jones 1983). This chapter discusses the role of site-specific promoter methylations in the control of gene expression. (For detailed information on the biochemistry and biology of DNA methylation, see Taylor 1984; Adams and Burdon 1985; Trautner 1984; Razin et al. 1984; and Cantoni and Razin 1985).

Keywords

Adenovirus Type Thymidine Kinase Gene Eukaryotic Gene Expression Nuclear Polyhedrosis Virus Autographa Californica Specific Sequence Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

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  • Walter Doerfler

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