Immunogenicity of Surfactant and Its Implications for Replacement Therapy

  • D. S. Strayer
  • T. A. Merritt
  • R. Spragg
  • M. Hallman
Conference paper


The etiology and pathogenesis of neonatal and adult respiratory distress syndromes (RDS) differ widely but share the characteristic inability of the lungs to adequately oxygenate the blood. Neonatal RDS occurs in premature infants deficient in surfactant (SRF) [1]. SRF deficiency causes alveoli to collapse on expiration, resulting in progressive respiratory failure. Because neonatal RDS directly reflects deficiency of surfactant, various investigators have tried therapeutic administration of heterologous, artificial, and homologous surfactants [2–4]. These preparations generally lower surface tension in vitro and in animal models, and are reported to be efficacious in infants with RDS.


Immune Complex Adult Respiratory Distress Syndrome Pulmonary Surfactant Congenital Toxoplasmosis Neonatal Respiratory Distress Syndrome 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. S. Strayer
  • T. A. Merritt
  • R. Spragg
  • M. Hallman

There are no affiliations available

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