Biology of Human Ovarian Cancer Xenografts
Abstract
In an attempt to establish human ovarian cancer tissue samples as subcutaneous xenografts in athymic (nu/nu) mice, our overall take rate was 32% and 11% of all specimens could be transferred beyond 3 passages. Transplantability was most successful if samples were derived from a metastatic lesion, contained a high number of mitotic figures and were not infiltrated by lymphocytes. The take rate was not dependent on the histologic subtype or the degree of differentiation.
All tumor lines thus far in use for chemotherapy studies have retained the histologic pattern of origin and have a consistent growth rate. At present our human ovarian cancer model contains a series of lines which vary in histologic subtype and tumor doubling time, differences that may also be expected in a group of ovarian cancer patients.
Keywords
Ovarian Cancer Histologic Subtype Alcian Blue Mitotic Figure Ovarian Cancer PatientPreview
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