The Effect of Sodium Bromide on Thyroid Function

  • F. X. R. van Leeuwen
  • R. Hanemaaijer
  • J. G. Loeber
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 12)


The thyroid-toxic properties of bromide ion were first observed more than a decade ago by Van Logten and co-workers (1974), studying the toxicological effects of sodium bromide. Although bromide ion is widely distributed in nature, forming a natural constituent of soil, plants, and animals, the main route of exposure of man stems from bromide residues present in food commodities as a result of the abundant use of bromide-containing pesticides, like methylbromide and ethylene dibromide, for soil fumigation in intensive horticulture and for postharvest treatment. Additional exposure may arise from the use of bromide-containing medicines. Although the prescibed use of these drugs is obsolete, in many countries over-the-counter sedatives still contain bromide. Thus uncontrolled self-medication may lead to chronic bromide intoxications (Van Leeuwen and Sangster 1987). The above-mentioned exposure of man to bromide was the reason for the interest of toxicologists in this ion.


Thyroid Gland Thyroid Peroxidase Sodium Bromide NADPH Cytochrome Thyroid Weight 
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  1. Alexander NM (1962) A spectrophotometric assay for iodide oxidation by thyroid peroxidase. Anal Biochem 4:341–345PubMedCrossRefGoogle Scholar
  2. Cleveland PD, Smuckler EA (1965) Effect of CCl4, dimethylnitrosamine and thioacetamide on hepatic DPNH and TPNH cytochrome c reductase. Proc Soc Exp Biol Med 120:808–810PubMedGoogle Scholar
  3. Engler H, Taurog A, Nakashima T (1982) Mechanism of inactivation of thyroid peroxidase by thioureylene drugs. Biochem Pharmacol 31(III):3801–3806PubMedCrossRefGoogle Scholar
  4. Hosoya T (1963) Effect of various reagents including antithyroid compounds upon the activity of thyroid peroxidase. J Biochem (Tokyo) 53(5):381–388Google Scholar
  5. Loeber JG, Franken MAM, van Leeuwen FXR (1983) The effects of sodium bromide on endocrine parameters in the rat as studied by immunocytochemistry and radioimmunoassay. Food Chem Toxicol 21:391–404PubMedCrossRefGoogle Scholar
  6. van Leeuwen FXR, Sangster B (1987) The toxicology of bromide ion. CRC Crit Rev Toxicol 18:189–213CrossRefGoogle Scholar
  7. van Leeuwen FXR, den Tonkelaar EM, van Logten MJ (1983) Toxicity of sodium bromide in rats: effect on endocrine system and reproduction. Food Chem Toxicol 21:383–389PubMedCrossRefGoogle Scholar
  8. van Logten MJ, Wolthuis M, Rauws AG, Kroes R, den Tonkelaar EM, Berkvens H, van Esch GJ (1974) Semichronic toxicity study of sodium bromide in rats. Toxicology 2:257–267PubMedCrossRefGoogle Scholar
  9. van Logten MJ, Rauws AG; Kroes R, den Tonkelaar EM, van Esch GJ (1976) Semichronic toxicity studies of sodium bromide in rats on a normal diet and a low chloride diet. Meded Fac Landbouww, Rijksuniv Gent 41(2): 1499–1507Google Scholar
  10. Yamamoto K, DeGroot LJ (1975) Participation of NADPH-cytochrome c reductase in thyroid hormone biosynthesis. Endocrinology 96:1022–1029PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. X. R. van Leeuwen
    • 1
  • R. Hanemaaijer
    • 1
  • J. G. Loeber
    • 2
  1. 1.Laboratory for ToxicologyNational Institute of Public Health and Environmental ProtectionBilthovenThe Netherlands
  2. 2.Laboratory for Clinical ChemistryNational Institute of Public Health and Environmental ProtectionBilthovenThe Netherlands

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