Glial Cells and Products of Activated Inflammatory Cells: Implications for Pathogenesis and Treatment of Multiple Sclerosis

  • R. P. Lisak
Conference paper


Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system of unknown etiology, but a disease in which immunopathologic events are likely important [1]. It is a chronic disease, frequently with an clinically relapsing course [2], but the pathologic processes may actually be continuous, although accentuated at times [3]. It also has a restricted age distribution, with the peak onset between 20 and 40 years of age. In addition to the inflammation, which is predominantly made up of monocyte-macrophage-microglia and lymphocytes and/ or their progeny, and demyelination, the other characteristic pathologic feature is gliosis [4]. This gliosis relates to the astrocytes, although there is some controversy as to whether these cells become more prominent, increase in number, or both.


Multiple Sclerosis Major Histocompatibility Complex Glial Cell Multiple Sclerosis Patient Experimental Allergic Encephalomyelitis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • R. P. Lisak
    • 1
    • 2
  1. 1.Departments of Neurology and Immunology and MicrobiologyWayne State University School of MedicineDetroitUSA
  2. 2.University of Pennsylvania School of MedicinePhialdelphiaUSA

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