Über die kardiostimulatorische und antiarrhythmische Wirkung von Sekretin
Conference paper
Zusammenfassung
Das von den Zellen der Duodenalmucosa gebildete Intestinalhormon Sekretin ist ein Polypetid von 27 Aminosäuren mit einem Molekulargewicht 3056; Glukagon dagegen, von den a-Zellen des Pankreas gebildet, ein Polypeptid von 29 Aminosauren und einem Molekulargewicht von 3485. Beim Vergleich der Primärstrukturen beider Peptide fällt auf, daß sich in den Aminosaurensequenzen 14 übereinstimmende Aminosäuren finden.
Preview
Unable to display preview. Download preview PDF.
Literatur
- 1.Burns, G. P. und W. G. Schenk, Effect of digestion and exercise on intestinal blood flow and cardiac output. Arch. Surg. 98, 790–794 (1969).PubMedGoogle Scholar
- 2.Butcher, R. W. und L. A. Carlson, Effects of secretin on fat mobilizing lipolysis and cyclic AMP levels in rat adipose tissue. Acta physiol. Scand. 79, 559–563 (1970).CrossRefGoogle Scholar
- 3.Cameron, A. J., S. F. Phillips und W. H. J. Summerskill, Comparison et effects of gastrin, cholecystokinin-pancreozymin, secretin, and glucagon on human stomach muscle in vitro. Gastroenterolgy 59, 539–545 (1970).Google Scholar
- 4.Cen, M., G. Rosenbusch, W. Frik und G. Kalff, Pharmakoangiographie des Pankreas mit Sekretin und Adrenalin. Dtsch. med. Wschr. 94, 1970–1972 (1969).Google Scholar
- 5.Chey, W. Y., S. Kosay, J. Hendricks, S. Bravermann und S. H. Lorber, Effect of secretin on motor activity of stomach and Heidenhain pouch in dogs. Amer. J. Physiol. 217, 848–852 (1969).PubMedGoogle Scholar
- 6.Cohn, K. E., J. Agmon und O. W. Gamble, The effect of glucagon on arrhythmias dlue to digitalis toxicity. Amer. J. Cardiol. 25, 683–689 (1970).PubMedCrossRefGoogle Scholar
- 7.Farah, A. und R. Tuttle, Studies on the pharmacology of glucagon. J. Pharmacol, exp. Ther. 129, 49–55 (1960).Google Scholar
- 8.Gerber, M. L., F. J. Hertzog, Y. P. Lee, J. B. Field und T. Drapanas, Effect of secretin on visceral hemodynamics and pancreatic function. Surg. Forum 18, 385–387 (1967).Google Scholar
- 9.Glick, G., W. W. Parmley, A. S. Wechsler und E. H. Sonnenblick, Glucagon: Its enhancement of cardiac performance in the cat and dog and persistence of its inotropic action despite beta-receptor blockade with propranolol. Circulat. Res. 22, 789–799 (1968).PubMedGoogle Scholar
- 10.Kock, N. G., N. Dorle und G. Dotevall, Inhibition of intestinal motility in man by glucagon given intraportally. Gastroenterology 53, 88–92 (1967).PubMedGoogle Scholar
- 11.Lazarus, N. R., W. R. Voyies, S. Devrim, T. Tanese und L. Recant, Extra gastro-intestinal effects of secretin, gastrin and pancreocymin. Lancet 1968, 2, 248–250.PubMedCrossRefGoogle Scholar
- 12.Levey, G. S. und S. E. Epstein, Activation of adenyl cyclase by glucagon in cat and human heart. Circulat. Res. 24, 151–156 (1969).PubMedGoogle Scholar
- 13.Lucchesi, B. R., Cardiac Actions of glucagon. Circulat. Res. 22, 777–787 (1968).PubMedGoogle Scholar
- 14.Lucchesi, B. R., D. R. Stutz und R. A. Winfield, Glucagon. Its enhancement of atrioventricular nodal pacemaker activity and failure to increase ventricular automaticity in dogs. Circulat. Res. 25, 183–190 (1969).PubMedGoogle Scholar
- 15.Luderitz B. und H.-D. Bolte, Zur kardialen Wirkung von Glukagon. Elektrophysiologische Messungen am Papillarmuskel des Herzens. Z. Kreislaufforschg. 60, 130–135 (1971).Google Scholar
- 16.Mayer, S. £., D. H. Namm und L. Rice, Effect of glucagon on ciclic 3’, 5’,-AMP, phosphorylase activity and contractility of heart muscle of the rat. Circulat. Res. 26, 225–233 (1970).Google Scholar
- 17.Murad, F. und M. Vaughan, Effect of glucagon on rat heart adenyl cyclase. Biochem. Pharmacol. 18, 1053–1059 (1969).PubMedCrossRefGoogle Scholar
- 18.Robinson, G. A., R. W. Butcher und E. W. Sutherland, Adenyl Cyclase as an adrenergic receptor. Ann. N. Y. Acad. Sci. 139, 703–723 (1967).CrossRefGoogle Scholar
- 19.Ross, G„ Cardiovascular effects of secretin. Amer. J. Physiol. 218 (4): 1166–1170 (1970).Google Scholar
- 20.Samols, E., G. Marri und V. Marks, Promotion of Insulin secretion by Glucagon. Lancet 1965/2, 415–416.Google Scholar
- 21.Sweeting, J. G., The effect of glucagon on bile and pancreatic juice. Gastroenterology 54, 1276 (1968).Google Scholar
- 22.Unger, R. H., H. Ketterer, A. Eisentraut und J. Dupre, Effect of secretin on insulin secretion. Lancet 1966/2, 24–26.Google Scholar
- 23.Vagne, M., F. Stening, F. P. Brooks und M. J. Grossmann, Synthetic secretin: comparison with natural secretin for potency and spectrum of physiological actions. Gastroenterology 55, 260–267 (1968).PubMedGoogle Scholar
- 24.Von Heimburg, R. L. und G. A. Hallenbeck, Inhibition of gastric secretion in dogs by glucagon given intraportally. Gastroenterology 47, 531–535 (1964).Google Scholar
Copyright information
© Dr. Dietrich Steinkopff Verlag, Darmstadt 1971