Molecular Mechanisms of Persistent Infection by Reovirus

  • T. S. Dermody
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 233/2)


Many cytolytic animal viruses are capable of establishing persistent infections of cultured cells. For such persistent infections to be maintained interactions between virus and cell must be modulated such that a less cytopathic virus-host relationship is established (reviewed in Ahmed et al. 1996). Variant viruses may be selected that are attenuated in cytolytic potential, or variant cells may be selected that are less permissive for viral replication. In some cases, however, viruses and cells coevolve during persistent infection, such that selection of virus-resistant cells leads to counterselection of highly infective mutant viruses that can grow in resistant cells.


Persistent Infection Ammonium Chloride Viral Entry Semliki Forest Virus Reovirus Infection 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • T. S. Dermody
    • 1
  1. 1.Departments of Pediatrics, and Microbiology and Immunology, and Elizabeth B. Lamb Center for Pediatric ResearchVanderbilt University School of MedicineNashvilleUSA

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