Regulation of Bacteriophage λ Replication

  • Karol Taylor
  • Grzegorz Węgrzyn
Part of the NATO ASI Series book series (volume 103)

Abstract

Bacteriophage λ is both a model for basic biological studies on the molecular level and a commonly used tool in molecular cloning. In this review we summarise the control of bacteriophage λ development, placing particular attention to the mechanisms involved in the “lysis or lysogeny” decision and the regulation of replication of phage λ DNA, as well as of plasmids derived from this phage.

Keywords

Bacteriophage λ control of virus development regulation of gene expression regulation of DNA replication molecular cloning 

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References

  1. Alfano C, McMacken R (1989) Heat shock protein-mediated disassembly of nucleoprotein structures is required for initiation of bacteriophage X DNA replication. J Biol Chem 264: 10709–10718PubMedGoogle Scholar
  2. Berg D (1974) Genes of phage lambda essential for Xdv plasmids. Virology 62: 224–233PubMedCrossRefGoogle Scholar
  3. Boyd AC, Sherratt DJ (1995) The CLIP plasmids: versatile cloning vectors based on the bacteriophage X origin of replication. Gene 153: 57–62PubMedCrossRefGoogle Scholar
  4. Chauthaiwale VM, Therwath A, Deshpande VV (1992) Bacteriophage lambda as a cloning vector. Microbiol Rev 56: 577–591PubMedGoogle Scholar
  5. Dodson M, Echols H,Wickner S, Alfano R. Mensa-Wilmot K, Gomes B, LeBowitz JH, Roberts JD, McMacken R (1986) Specialized nucleoprotein structures at the origin of replication of bacteriophage X: localized unwinding of duplex DNA by six-protein reaction. Proc Natl Acad Sci USA 83: 7638–7642PubMedCrossRefGoogle Scholar
  6. Echols H (1986) Bacteriophage X development: temporal switches and the choice of lysis or lysogeny. Trends Genet 2: 26–30CrossRefGoogle Scholar
  7. Friedman DI, Court DL (1995) Transcription antitermination: the X paradigm updated. Mol Microbiol 18: 191–200PubMedCrossRefGoogle Scholar
  8. Georgopoulos C, Welch WJ (1993) Role of the major heat shock proteins as molecular chaperones. Annu Rev Cell Biol 9: 601–634PubMedCrossRefGoogle Scholar
  9. Giladi H, Goldenberg D, Koby S, Oppenheim AB (1995) Enhanced activity of the bacteriophage X PL promoter at low temperature. FEMS Microbiol Rev 17: 135–140PubMedGoogle Scholar
  10. Gottesman S, Clark WP, de Crecy-Lagard V, Maurizi MR (1993) CIpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. J Biol Chem 268: 22618–22626PubMedGoogle Scholar
  11. Hendrix RW, Roberts JW, Stahl FW, Weisberg RA, eds. (1983) Lambda II. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NYGoogle Scholar
  12. Herman C, Ogura T, Tomoyasu T, Hiraga S, Akiyama Y, Ito K, Thomas R, D’Ari R, Bouloc P (1993) Cell growth and X phage development controlled by the same essential Escherichia coligene fsHíhflB. Proc Natl Acad Sci USA 90: 10861–10865PubMedCrossRefGoogle Scholar
  13. Herskowitz I (1985) Master regulatory loci in yeast and lambda. Cold Spring Harbor Symp Quant Biol 50: 565–574PubMedGoogle Scholar
  14. Kleckner N, Signer E (1977) Genetic characterization of plasmid formation of Nmutants of bacteriophage X. Virology 79: 160–173PubMedCrossRefGoogle Scholar
  15. Klinkert J, Klein A (1978) Roles of bacteriophage lambda gene products Oand Pduring early and late phases of infection cycle. J Viro125: 730–737Google Scholar
  16. Learn B, Karzai AW, McMacken R (1993) Transcription stimulates the establishment of bidirectional X DNA replication in vitro. C S H Symp Quant Biol 58: 389–402Google Scholar
  17. Liberek K, Georgopoulos C, Zylicz M (1988) Role of Escherichia coliDnaK and DnaJ heat shock proteins in the initiation of bacteriophage X DNA replication. Proc Natl Acad Sci USA 85: 6632–6636PubMedCrossRefGoogle Scholar
  18. Maruyama IN, Maruyama HI, Brenner S (1994) Xfoo: a X phage vector for the expression of foreign proteins. Proc Natl Acad Sci USA 91: 8273–8277PubMedCrossRefGoogle Scholar
  19. Matsubara K (1976) Genetic structure and regulation of a replicon of plasmid Xdv. J Mol Biol 102: 427–439PubMedCrossRefGoogle Scholar
  20. Matsubara K (1981) Replication control system in lambda dv. Plasmid 5: 32–52PubMedCrossRefGoogle Scholar
  21. Matsubara K, Mukai T (1975) Mode of replication of plasmid Xdv. J Biochem 77: 373–382PubMedGoogle Scholar
  22. Matsubara K, Mukai T (1975) Mode of replication of plasmid Xdv. J Biochem 77: 373–382PubMedGoogle Scholar
  23. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NYGoogle Scholar
  24. Sternberg N, Hoess RH (1995) Display of peptides and proteins on the surface of bacteriophage X. Proc Natl Acad SciTJSA 92: 1609–1613CrossRefGoogle Scholar
  25. Szalewska A, Węgrzyn G, Taylor K (1994) Neither absence nor excess of X O initiator-digesting C1pXP protease affects X plasmid or phage replication in Escherichia coli. 13: 469–474Google Scholar
  26. Szalewska-Palasz A, Węgrzyn A, Herman A, Węgrzyn G (1994) The mechanism of the stringent control of X plasmid DNA replication. EMBO J 13: 5779–5785PubMedGoogle Scholar
  27. Szalewska-Palasz A, Węgrzyn A, Obuchowski M, Pawlowski R, Bielawski K, Thomas MS, Węgrzyn G (1996) Drastically decreased transcription from CH-activated promoters is responsible for impaired lysogenization of the Escherichia coli rpoA341mutant by bacteriophage X. FEMS Microbiol Lett 144: 21–27PubMedCrossRefGoogle Scholar
  28. Thomas R (1993) Bacteriophage X: transactivation, positive control and other odd findings. BioEssays 15: 285–289Google Scholar
  29. Węgrzyn A, Węgrzyn G, Taylor K (1995a) Protection of coliphage XO initiator protein from proteolysis in the assembly of the replication complex in vivo. Virology 207: 179–184CrossRefGoogle Scholar
  30. Węgrzyn A, Węgrzyn G, Taylor K (1995b) Plasmid and host functions required for X plasmid replication carried out by the inherited replication complex. Mol Gen Genet 247: 501–508CrossRefGoogle Scholar
  31. Węgrzyn A, Węgrzyn G, Taylor K (1996a) Disassembly of the coliphage X replication complex due to heat shock induction of the groEoperon. Virology 217: 594–597CrossRefGoogle Scholar
  32. Węgrzyn A, Węgrzyn G, Herman A, Taylor K (1996b) Protein inheritance: X plasmid replication perpetuated by the heritable replication complex. Genes to Cells 1Google Scholar
  33. Węgrzyn G (1995) Amplification of X plasmids in Escherichia coli relAmutants. J B iotechnol 43: 139–143Google Scholar
  34. Węgrzyn G, Taylor K (1992) Inheritance of the replication complex by one of two daughter copies during X plasmid replication in Escherichia coli. J Mol Biol 226: 681–688PubMedCrossRefGoogle Scholar
  35. Węgrzyn G, Pawlowicz A, Taylor K (1992) Stability of coliphage X DNA replication initiator, the XO protein. J Mol Biol 226: 675–680PubMedCrossRefGoogle Scholar
  36. Węgrzyn G, Szalewska-Palasz A, Węgrzyn A, Obuchowski M, Taylor K (1995a) Transcriptional activation of the origin of coliphage X DNA replication is regulated by the host DnaA initiator function. Gene 154: 47–50CrossRefGoogle Scholar
  37. Węgrzyn G, Węgrzyn A, Konieczny I, Bielawski K, Konopa G, Obuchowski M, Helinski DR, Taylor K (1995b) Involvement of the host initiator function dnaAin the replication of coliphage X. Genetics 139: 1469–1481Google Scholar
  38. Węgrzyn G, Węgrzyn A, Pankiewicz A, Taylor K (1996) Allele specificity of the Escherichia coli dnaAgene function in the replication of plasmids derived from phage X. Mol Gen Genet 252: 580–586PubMedGoogle Scholar
  39. Zvlicz M (1993) The Escherichia colichaperones involved in DNA replication. Phil Trans R Soc London B 339: 271–278CrossRefGoogle Scholar
  40. Zylicz M. Górska I, Taylor K, Georgopoulos C (1984) Bacteriophage X replication proteins: formation of a mixed oligomer and binding to the origin of X DNA. Mol Gen Genet 196: 401–406PubMedCrossRefGoogle Scholar
  41. Żylicz M, Ang D, Liberek K. Georgopoulos C (1989) Initiation of X DNA replication with purified host-and bacteriophage-encoded proteins: role of the DnaK, DnaJ and GrpE heat shock proteins. EMBO J 8: 1601–1608PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Karol Taylor
    • 1
  • Grzegorz Węgrzyn
    • 1
  1. 1.Department of Molecular BiologyUniversity of GdańskGdańskPoland

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