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CNS Neurons: The Basis and Benefits of Low Class I Major Histocompatibility Complex Expression

  • Glenn F. Rall
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 232)

Abstract

The host immune response is generally thought to consist of cells with “professional” immunologic functions, such as B and T cells, macrophages, and natural killer (NK) cells. However, differentiated cells which do not normally participate in immune surveillance may be recruited to serve an integral function in the immune-mediated elimination of foreign intracellular pathogens such as viruses. As discussed elsewhere in this volume, most cells have the ability to present immunogenic, “non-self” peptides (called epitopes) in association with “self&” class I major histocompatibility complex (MHC) molecules. This cell surface complex is engaged by the T cell receptor (TCR) of cytotoxic T lymphocytes (CTL). Appropriate MHC-epitope-TCR interaction leads to the CTL-mediated lysis of the epitope-expressing target cell via the perforation of the plasma membrane, introduction of CTL-derived proteolytic enzymes (granzymes) into the target cell cytosol, and eventual cell death, presumably via apoptosis.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Central Nervous System Neuron Measle Virus Infection Major Histocompatibility Complex Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Glenn F. Rall
    • 1
  1. 1.Department of Basic Science, Divisions of Virology and ImmunologyThe Fox Chase Cancer CenterPhiladelphiaUSA

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