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The Roles of α4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus

  • S. A. Michie
  • H.-K. Sytwu
  • J. O. McDevitt
  • X.-D. Yang
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 231)

Abstract

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer’s patches (PP), then to lymph and back to blood (Gowans and Knight 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (Mackay et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (Carlos and Harlan 1994; Imhof and Dunon 1995; Butcher and Picker 1996).

Keywords

Lacrimal Gland Experimental Allergic Encephalomyelitis Nonobese Diabetic Mouse Lymphocyte Migration Lymphocyte Homing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • S. A. Michie
    • 1
    • 2
  • H.-K. Sytwu
    • 3
  • J. O. McDevitt
    • 3
    • 4
  • X.-D. Yang
    • 5
  1. 1.Department of Veterans AffairsPalo Alto Health Care System, Center for Molecular Biology in MedicinePalo AltoUSA
  2. 2.Department of PathologyStanford University School of MedicineStanfordUSA
  3. 3.Department of Microbiology and ImmunologyStanford University School of MedicineStanfordUSA
  4. 4.Department of MedicineStanford University School of MedicineStanfordUSA
  5. 5.Division of Preclinical ResearchAbgenix, Inc.FremontUSA

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