Design and Synthesis of Organic Molecules Based on Molecular Recognition

  • Ephraim Katchalski-Katzir
Conference paper

Abstract

A great deal of work has been carried out by chemists, physicists and physical chemistry in order to gain a better understanding of the principles determining specific molecular interaction [1–3]. The biologist, of course, is well aware of specific biological reactions in practically every field of study in which he is involved. Specific biological reactions occur in many of the vital life processes, such as the interactions between enzymes and their corresponding substrates and inhibitors, between hormones and their receptors, between antibodies and antigens, and between cell and cell. Powerful physical techniques such as X-ray and NMR have made it possible to determine on an atomic level the conformation of some important biopolymers — enzymes, antibodies and nucleic acids — and to shed new light on the atomic structure of the molecular domains responsible for the specific interactions exhibited by these macromolecules. Furthermore, analysis of the conformation of specific biopolymer-ligand complexes, using the above techniques, has opened up new possibilities for the evaluation of the forces and energetics involved, and led to the elucidation of some of the molecular mechanisms that characterize biocatalysis.

Keywords

Guest Molecule Reverse Micelle Molecular Recognition Molecular Biologist Streptomyces Griseus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Ephraim Katchalski-Katzir
    • 1
    • 2
  1. 1.The Weizmann Institute of ScienceRehovotIsrael
  2. 2.The Center for BiotechnologyTel-Aviv UniversityRamat AvivIsrael

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