• D. S. Paskov
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 79)


The alkaloid galanthamine is a valuable product from the group of natural anticholinesterase substances. It was the first isolated by Proskurnina and Yakovleva (1952) from Galanthus woronowi Los., family amaryllidaceae. Uyeo and Kobayashi (1953) isolated the same alkaloid from Lycoris radiata Herb., and called it lycoremine. Later, galanthamine was found in more than 50 species of the family Amaryllidaceae (Boit 1961). Yunusov and Abduazimov (1957) isolated galanthamine from various Ungernia species, Ungernia victoris Vved. proved to be the richest. In Bulgaria, galanthamine, isolated from Galanthus nivalis L. var. gracilis Čelak, family Amaryllidaceae, was studied and put into practice under the name Nivalin (Paskov 1957; Ivanova-Bubeva 1957). Later, a high galanthamine content was found in the plant Leucojum aestivum L., also family Amaryllidaceae, growing within the territory of Bulgaria (Ivanova-Bubeva and Ivanov 1961; Stefanov et al. 1974). At present, galanthaminum is manufactured industrially in the USSR from Ungernia vicions and in Bulgaria from Leucojum aestivum.


Nictitate Membrane Human Peripheral Lymphocyte Polychromatic Erythrocyte Potassium Bichromate Progressive Muscular Dystrophy 
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