The Current State of rCBF, rCMRO2, rCBV, and rCMRGlu Studies at the Hammersmith Hospital

  • J. M. Gibbs
  • R. S. J. Frackowiak
  • R. J. S. Wise
  • A. A. Lammertsma
  • C. G. Rhodes
  • T. Jones
Chapter

Abstract

The development of positron emission tomography (PET) represents an important advance in the study of cerebral tissue function in man. By virtue of the characteristic double photon signal from positron emitting isotopes and tomographic reconstruction using paired coincidence detectors, precise regional measurements can be made of cerebral isotope concentration throughout a tomographic slice of brain. PET is thus a noninvasive, in vivo equivalent of the autoradiographic technique applied to experimental animals. Furthermore, the development of a variety of tracer models has led to the measurement not only of regional cerebral blood flow and blood volume, but also of local metabolic activity and its relationship to the available blood supply. Labeling of drugs and neurotransmitter precursors is further expanding the range of applications for PET in the study of both normal and abnormal cerebral physiology.

Keywords

Positron Emission Tomography Positron Emission Tomography Study Regional Cerebral Blood Flow Cereb Blood Flow Carotid Artery Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Heidelberg 1985

Authors and Affiliations

  • J. M. Gibbs
    • 1
  • R. S. J. Frackowiak
    • 1
  • R. J. S. Wise
    • 1
  • A. A. Lammertsma
    • 1
  • C. G. Rhodes
    • 1
  • T. Jones
    • 1
  1. 1.MRC Cyclotron Unit and Department of NeurologyHammersmith HospitalLondonGreat Britain

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