Subacute and Subchronic Toxicity of Dietary Bendiocarb in Rats

Abstract

The toxic effects of dietary bendiocarb (2,2-dimethyl-1,3-benzodioxol-4-yl-methylcarbamate) (25 and 250 ppm) in rats were studied.

Feeding bendiocarb at the levels employed produced no visible toxic manifestations.

In animals fed diets with bendiocarb, no statistically significant difference in body weight gain was observed when compared with control animals. Feeding 250 ppm bendiocarb for a 30 and 90 days, and 25 ppm for a 90 days produced significant reduction of cholinesterase activity in blood, but 25 ppm bendiocarb for a 30 days produced no alteration of cholinesterase activity.

Statistically significant reduction in the transaminases SGOT and SGPT activity was found in male and female rats fed 250 ppm bendiocarb. At the same time, no statistically significant difference in serum enzyme activity was observed in animals fed diet containing 25 ppm bendiocarb, except for SGPT activity in male rats fed diets with bendiocarb for a period of 90 days.

Hematological data showed that bendiocarb (250 ppm) caused an increase in hemoglobin concentration and total white blood cell number. The differences were statistically significant.