The Selective Origin of Linkage Disequilibrium in the HLA Region

  • W. Klitz
  • G. Thomson
Conference paper

Abstract

The linkage disequilibrium patterns observed between tightly linked loci, such as the HLA loci, can indicate the nature of evolutionary events, particularly selection events, acting on the region. We have developed a method, disequilibrium pattern analysis, for examining the disequilibrium distribution of a population of two-locus haplotypes. Specific quantifiable patterns are predicted as a result of selective events.

Keywords

Factor Xiii Linkage Disequilibrium Pattern Positive Space Negative Space Coagulation Factor Xiii 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Reference

  1. 1.
    Hansen HE, Larsen SO, Ryder LP, Nielsen LS (1979) HLA-A, B haplotype frequencies in 5202 unrelated Danes by a maximum likelihood method of gene counting. Tissue Antigens 13: 143–153PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • W. Klitz
    • 1
  • G. Thomson
    • 1
  1. 1.Genetics DepartmentUniversity of CaliforniaBerkeleyUSA

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