Spleen Focus-Forming Virus: Relationship of an Altered Envelope Gene to the Development of a Rapid Erythroleukemia

  • S. Ruscetti
  • L. Wolff
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 112)

Abstract

In the 26 years since “Friend virus” was discovered (Friend 1957), we have learned a considerable amount about this virus complex and the role of the various components in the development of erythroleukemia in the mouse. The biological and molecular cloning of these viral components has been pivotal in carrying out these studies. Separation in rodent fibroblasts of Friend murine leukemia virus (F-MuLV) and the defective spleen focus-forming virus (SFFV) has led to the conclusion that SFFV is responsible for the rapid erythroleukemia occurring in adult mice, while the role of F-MuLV in the adult is to act as a helper for the replicative functions that the defective SFFV lacks. Molecular cloning of SFFV as well as the isolation of biological mutants of SFFV has allowed for the localization of the region of the viral genome involved in pathogenicity. This region includes almost exclusively the envelope gene of SFFV. The focus of this review, therefore, will be on studies of the envelope gene of various SFFVs and their translational products.

Keywords

Erythroid Differentiation Helper Virus Envelope Gene Friend Virus Erythroid Precursor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • S. Ruscetti
    • 1
  • L. Wolff
    • 1
  1. 1.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA

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