ZAK Zürich pp 206-214 | Cite as

Intermediär- und Endprodukte der klassischen Kaskadensysteme und des Arachidonsäuresystems als potentielle Mediatoren beim akuten Lungenversagen (ARDS)

  • H. Neuhof
  • W. Seeger
Conference paper
Part of the Anaesthesiologie und Intensivmedizin/Anaesthesiology and Intensive Care Medicine book series (A+I, volume 187)

Zusammenfassung

Bei allen ein akutes Lungenversagen auslösenden Affektionen sind immer, wenn auch mit unterschiedlicher Akzentuierung, die klassischen Kaskadensysteme (das Kallikrein-Kinin-System, das Komplementsystem und das Gerinnungssystem) aktiviert [23,24,29,39,41,53]. Alle 3 Systeme liefern Intermediär- und Endprodukte, die einerseits eigene direkte Gefäßwirkungen ausüben und andererseits den Arachidonsäuremetabolismus stimulieren und zur Bildung von vasoaktiven Eicosanoiden (Metabolite der Arachidonsäure) anregen.

This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Anderson FL, Tsagaris TJ, Jubiz W, Kuida H (1975) Prostaglandin F and E levels during endotoxin-induced pulmonary hypertension in calves. Am J Physiol 228: 1479–1482PubMedGoogle Scholar
  2. 2.
    Anderson FL, Jubiz W, Tsagaris TJ, Kuida H (1975) Endotoxin-induced prostaglandin E und F release in dogs. Am J Physiol 228: 410–414PubMedGoogle Scholar
  3. 3.
    Anhut H, Peskar BA, Bernauer W (1978) Release of 15-keto-13,14-dihydrothromboxan B2 and prostaglandin during anaphylaxis as measured by radioimmunoassay. Naunyn Schmiedebergs Arch Pharmacol 305: 247–252PubMedCrossRefGoogle Scholar
  4. 4.
    Barnhart MI, Chen S (1978) Platelet — vessel wall dynamics. Thromb Haemost [Suppl] 63: 301–317Google Scholar
  5. 5.
    Baumgartner HR, Muggli R, Tschopp TB, Turito VT (1976) Platelet adhesion, release and aggregation in flowing blood: Effects of surface properties and platelet function. Thromb Haemost 35: 124–138PubMedGoogle Scholar
  6. 6.
    Bayley T, Clements JA, Osbahr AJ (1967) Pulmonary and circulatory effects of fibrinopeptides. Circ Res 21: 469–485PubMedGoogle Scholar
  7. 7.
    Becker EL, Showell HJ, Henson PM, Hsu LS (1974) The ability of chemotactic factors to induce lysosomal enzyme release. J Immunol 112: 2047–2054PubMedGoogle Scholar
  8. 8.
    Belew M, Gerdin B, Porath J, Saldeen J, Saldeen T (1978) Isolation of vasoactive peptides from human fibrin and fibrinogen degradated by p las min. Thromb Res 13: 983–994PubMedCrossRefGoogle Scholar
  9. 9.
    Borgeat P, Samuelsson B (1979) Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. J Biol Chem 254: 7865–7869PubMedGoogle Scholar
  10. 10.
    Busch C, Gerdin B (1981) Effect of low molecular weight fibrin degradation products on endothelial cells in culture. Thromb Res 22: 33–39PubMedCrossRefGoogle Scholar
  11. 11.
    Cook JA, Wise WC, Halushka PV (1980) Elevated thromboxane levels in rat during endo toxic shock. J Clin Invest 65: 227–230PubMedCrossRefGoogle Scholar
  12. 12.
    Craddock PR, Fehr J, Brigham KL et al (1977) Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis. T N Engl J Med 296: 769–774CrossRefGoogle Scholar
  13. 13.
    Craddock PR, Hammerschmidt D, White JG, Dalmasso AP, Jacob HS (1977) Complement ( C5a)- Induced granulocyte aggregation in vitro. J Clin Invest 60: 260–264PubMedCrossRefGoogle Scholar
  14. 14.
    Dahlén S-E, Björk J, Hedqvist P et al (1981) Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: In vivo effects with relevance to the acute inflammatory response. Proc Natl Acad Sci 78: 3887–3891PubMedCrossRefGoogle Scholar
  15. 15.
    Eisen V, Walker DI, Binysh SG, Tedder RS (1977) Prostaglandins and complement changes in some conditions related to inflamation. Agents Actions 2: 99–108Google Scholar
  16. 16.
    Fritz H, Duswald KH, Dittmer H, Kortmann H, Neumann S, Lang H, Jochum M (1984) Granulocyte proteinases as mediators of unspecific proteolysis in inflammation. In: Goldberg DM, Werner M (eds) Selectic topics in clinical enzymology, vol. II. de Gruyter, Berlin New YorkGoogle Scholar
  17. 17.
    Fröhlich JC, Ogletree M, Peskar BA, Brigham KL (1980) Pulmonary hypertension correlated to pulmonary thromboxane synthesis. In: Samuelsson B, Ramwell PW, Paoletti R (eds) Advances in prostaglandin and thromboxane research, vol 7. Raven, New York, p 745Google Scholar
  18. 18.
    Gallin JI (1976) The role of Chemotaxis in the inflammatory-immune response of the lung. In: Kirkpatrik CH, Reynolds HY (eds) Immunologic and infections in the lung. Dekker, New York Basel, pp 161–178Google Scholar
  19. 19.
    Gerdin B, Belew M, Lindquist O, Saldeen T (1979) Effect of a fibrin-derived peptide on pulmonary microvascular permeability. In: Saldeen T (ed) The mieroembolism syndrom. Almquist & Wiksell, Stockholm, pp 233–239Google Scholar
  20. 20.
    Gersmeyer EF, Spitzbarth H (1961) Über Kreislaufwirkungen von synthetischem Bradykinin beim Menschen und beim wachen Hund. Klin Wochenschr 39: 1227–1233PubMedCrossRefGoogle Scholar
  21. 21.
    Goldstein IM, Roos D, Kaplan HB, Weissmann G (1975) Complement and immunoglobins stimulate Superoxide production by human leukocytes independently of phagocytosis. J Clin Invest 56: 1155–1163PubMedCrossRefGoogle Scholar
  22. 22.
    Heflin AC, Brigham LK (1981) Prevention by granulocyte depletion of increased vascular permeabil¬ity of sheep lung following endotoxemia. J Clin Invest 68: 1253–1260PubMedCrossRefGoogle Scholar
  23. 23.
    Heideman M, Kaijser B, Gelin L-E (1978) Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury. J Trauma 18: 696–700PubMedCrossRefGoogle Scholar
  24. 24.
    Heideman M, Kaijser B, Gelin L-E (1979) Complement activation early in endotoxin shock. J Surg Res 26: 74–78PubMedCrossRefGoogle Scholar
  25. 25.
    Hong SL, Levine L (1976) Stimulation of prostaglandin synthesis by bradykinin and thrombin and their mechanism of action on MCS-fibroblasts. J Biol Chem 251: 5814–5816PubMedGoogle Scholar
  26. 26.
    Jacob HS, Craddock PR, Hammerschmidt DE, Moldow CF (1980) Complement-induced granulocyte aggregation. N Engl J Med 302: 789–794PubMedCrossRefGoogle Scholar
  27. 27.
    Kadish JL, Butterfield CE, Folkman J (1979) The effect of fibrin on cultured vascular endothelial cells. Tissue Cell 11: 99–108PubMedCrossRefGoogle Scholar
  28. 28.
    König W, Bohn A, Bremm KD, Müller P, Szperalski B, Pfeiffer P (1982) Leukotrienes and lipoxygenase-factors: Mediators and modulators of the allergic reaction. Allergol Immunopathol (Madr) 10 /5: 385–394Google Scholar
  29. 29.
    Lasch HG, Heene DL, Huth K, Sandritter W (1967) Pathophysiology, clinical manifestations and therapy of consumption-coagulopathy („Verbrauchskoagulopathie“). Am J Cardiol 20: 381PubMedCrossRefGoogle Scholar
  30. 30.
    Lefer AM (1982) Vascular mediators in ischemia and shock. In: Cowley RA, Trump BF (eds) Pathophysiology of shock, anoxia and ischemia. Wilhams & Wilkins, Baltimore London, pp 165–181Google Scholar
  31. 31.
    Lough J, Moore S (1975) Endothelial injury induced by thrombin or thrombi. Lab Invest 33: 130–135PubMedGoogle Scholar
  32. 32.
    Manwarning D, Curreri PW (1982) Platelet and neutrophil sequestration after fragment D-induced respiratory distress. Circ Shock 9: 75–80Google Scholar
  33. 33.
    Manwarning D, Thorning D, Curreri PW (1978) Mechanisms of acute pulmonary dysfunction induced by fibrinogen degradation product D. Surgery 84: 45–54Google Scholar
  34. 34.
    McDonald JA, Baum BJ, Rosenberg DM et al (1979) Destruction of a major extracellular adhesive glycoprotein (fibronectin) of human fibroblasts by neutral proteases from polymorphonuclear leukocyte granules. Lab Invest 40: 350–357PubMedGoogle Scholar
  35. 35.
    McGuire WW, Spragg RG, Cohen AB, Cochrane CG (1982) Studies of the pathogenesis of the adult respiratory distress syndrome. J Clin Invest 69: 543–553PubMedCrossRefGoogle Scholar
  36. 36.
    Moncada S, Vane JR (1978) Unstable metabolites of arachidonie acid and their role in haemostasis and thrombosis. Br Med Bull 34: 129–135PubMedGoogle Scholar
  37. 37.
    Müller-Esterl W, Rauth G, Fritz H, Lottspeich F, Henschen A (1983) Human kininogens. In: Haberland GL, Rohen JW, Fritz H, Huber P (eds) Kininogenases. Schattauer, Stuttgart New York, pp 3–28Google Scholar
  38. 38.
    Mullane KM, Moncada S (1980) Prostacyclin release and the modulation of some vasoactive hormones. Prostaglandins 20: 25–49PubMedCrossRefGoogle Scholar
  39. 39.
    Neuhof H (1981) Blood coagulation in hemorrhagic shock. In: Rügheimer E, Zindler M (eds) Anaesthesiology. Excerpta Medica, Amsterdam Princeton, p 538Google Scholar
  40. 40.
    Neuhof H, Lasch HG (im Druck) Interaction between intravascular coagulation and tissue perfusion. Clin HemorheologyGoogle Scholar
  41. 41.
    Neuhof H, Sablofski I, Wilhelmi J, Hey D, Lasch HG (1977) Activation of intravascular coagulation by bromocarbamide. Int J Clin Pharmacol 15: 176–180Google Scholar
  42. 42.
    Neuhof H, Seeger W, Wolf HRD, Hall J, Neumann C, Srampical B (im Druck) Acute increase in pulmonary vascular resistance induced by circulating fibrin monomers, mediated by pulmonary thromboxane A2 generation. Eur J Respir DisGoogle Scholar
  43. 43.
    Ogletree M, Brigham KL (1979) Indomethacin augments endotoxin induced increased lung vascular permeability in sheep. Rev Respir Dis 119: 383Google Scholar
  44. 44.
    Palmer MA, Piper PJ, Vane JR (1973) Release of rabbit aorta contracting substance ( RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs. Br J Pharmacol 49: 226–242PubMedGoogle Scholar
  45. 45.
    Platshon LF, Kaliner M (1978) The effects of the immunologic release of histamine upon human lung cyclic nucleotide levels and prostaglandin generation. J Clin Invest 62: 1113–1121PubMedCrossRefGoogle Scholar
  46. 46.
    Polley MJ, Nachman RL, Weksler BB (1981) Human complement in the arachidonic acid transformation pathway in platelets. J Exp Med 153: 257–268PubMedCrossRefGoogle Scholar
  47. 47.
    Riede UN, Mittermayer C, Rohrbach R, Joh K, Vogel W, Fringes B (1982) Mikrothrombosierung der Endstrombahn als Ursache schockbedingter Organkomplikationen (unter besonderer Berücksichtigung der Schocklunge). Haemostasiologie 2: 3–24Google Scholar
  48. 48.
    Saba TM, Jaffe E (1980) Plasma fibronectin ( Opsonic glycoprotein ): Its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am J Med 68: 577–594PubMedCrossRefGoogle Scholar
  49. 49.
    Sacks T, Moldow CF, Craddock PR et al (1978) Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. J Clin Invest 61: 1161–1167PubMedCrossRefGoogle Scholar
  50. 50.
    Saldeen T (1979) Blood coagulation and shock. Pathol Res Pract 165: 221–252PubMedCrossRefGoogle Scholar
  51. 51.
    Saldeen T (1980) Fibrin derived peptides as mediators of increased vascular permeability. Acta Chir Seand [Suppl] 499: 67–72Google Scholar
  52. 52.
    Samuelsson B, Borgeat P, Hammarström S, Murphy RC (1980) Leucotrienes: A new group of biologically active compounds. In: Samuelsson B, Ramwell P, Paoletti R (eds) Advances in prostaglandin and thromboxane research, vol 6. Raven, New York, pp 1–18Google Scholar
  53. 53.
    Saugstad OD, Aasen AO, Guldvog I et al (1980) Activation of the kallikreinkinin system during experimental lung insufficiency in dogs. Acta Chir Scand [Suppl] 499: 123–129Google Scholar
  54. 54.
    Schlag G, Redl H (1980) Die Leukostase in der Lunge beim hypovolämisch-traumatischen Schock. Anaesthesist 29: 606–612PubMedGoogle Scholar
  55. 55.
    Schrör K (1982) Bedeutung von Prostaglandinen und anderen Eicosanoiden für das Verhalten der Mikrozirkulation beim Schock. Hamostasiologie 2: 73–81Google Scholar
  56. 56.
    Seeger W, Neuhof H, Graubert E, Wolf H, Rdka L: Comparative influence of the Ca-ionophore A 23187, bradykinin, kallidin and eledoisin an the rabbit pulmonary vasculature with special reference to arachidonate metabolism. In: Kinins III. Plenum Publishing CorporationGoogle Scholar
  57. 57.
    Seeger W, Wolf H, Stahler G, Neuhof H, Róka L (1982) Increased pulmonary vascular resistance and permeability due to arachidonate metabolism in isolated rabbit lungs. Prostaglandins 23: 157–173PubMedCrossRefGoogle Scholar
  58. 58.
    Sheppard BL, French JE (1974) Platelet adhesion in the rabbit abdominal aorta following the removal of the endothelium: A scanning and transmission electron microscopical study. Proc R Soc Lond [Biol] 176: 427–423CrossRefGoogle Scholar
  59. 59.
    Stimler NP, Brocklehurst WE, Bloor CM, Hugli TE (1980) Complement anaphylatoxin C5a stimulates release of SRS-A-like activity from guinea-pig lung fragments. J Pharm Pharmacol 32: 804PubMedCrossRefGoogle Scholar
  60. 60.
    Tucker A, Weir EK, Reeves JT, Grover RF (1976) Pulmonary microembolism: Attenuated vasoconstriction with prostaglandin inhibitors and antihistamines. Prostaglandins 11: 31–41PubMedCrossRefGoogle Scholar
  61. 61.
    Williams TJ, Jose PJ (1981) Mediation of increased vascular permeability after complement activation. J Exp Med 153: 136–153PubMedCrossRefGoogle Scholar
  62. 62.
    Wilson JW (1972) Leukocyte sequestration and morphologic augmentation in the pulmonary network following hemorrhagic shock and related forms of stress. Adv Microcirc 4: 197–232Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • H. Neuhof
  • W. Seeger

There are no affiliations available

Personalised recommendations