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Fatty Acid Binding: A New Kind of Posttranslational Modification of Membrane Proteins

  • Michael F. G. Schmidt
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 102)

Abstract

Many cellular functions are carried out by proteins which are in close association with lipid bilayers. The key structure for regulating many of the cell’s activities as a function of the various environmental stimuli is the cell surface membrane. In this regulation, membrane proteins of the cell surface are of utmost importance for receiving extracellular signals as, for instance, through the binding of antigens, hormones, neurotransmitters, lectins, antibodies, neighboring cells, or viruses. The receptors themselves, or other membrane proteins, then transduce information to the appropriate intracellular sites where specific biochemical responses are induced, often including the participation of internal membranes.

Keywords

Influenza Virus Newcastle Disease Virus Vesicular Stomatitis Virus Viral Glycoprotein Semliki Forest Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Agrawal HC, Burton RM, Fishman MA, Mitchell RF, Prensky AL (1972) Partial characterization of a new myelin protein component J Neurochem 19:2083–2089PubMedGoogle Scholar
  2. Agrawal HC, Randle CL, Agrawal D (1982) In vivo acylation of rat brain myelin proteolipid protein. J Biol Chem 257:4588–4592PubMedGoogle Scholar
  3. Ahkong QF, Fisher D, Tampion W, Lucy JA (1973) The fusion of erythrocytes by fatty acids, esters, retinal, and α-tocopherol. Biochem J 136:147–155PubMedGoogle Scholar
  4. Ashwell G, Morell AG (1974) The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adv Enzymol 41:99–128PubMedGoogle Scholar
  5. Awasthi YC, Chuang TF, Keenan TW, Crane FL (1971) Tightly bound cardiolipin in cytochrome oxidase. Biochem Biophys Acta 226:42–52PubMedGoogle Scholar
  6. Azzi A, Brodbeck V, Zahler P (eds) (1981) Membrane proteins -a laboratory manual. Springer, Berlin Heidelberg New YorkGoogle Scholar
  7. Bar-Nun S, Kreibich G, Adesnik M, Alterman L, Negishi M, Sabatini DD (1980) Synthesis and insertion of cytochrome p-450 into endoplasmic reticulum membranes. Proc Natl Acad Sci USA 77:965–969PubMedGoogle Scholar
  8. Bell RM, Coleman RA (1980) Enyzmes of glycerolipid synthesis in eukaryotes. Annu Rev Biochem 49:459–487PubMedGoogle Scholar
  9. Bergmann JE, Tokuyasu KT, Singer SJ (1981) Passage of an integral membrane protein the vesicular stomatitis virus glycoprotein through the Golgi apparatus en route to the plasma membrane. Proc Natl Acad Sci USA 78:1746–1750PubMedGoogle Scholar
  10. Blobel G (1979) From gene to protein. In: Russel TR, Brew K, Faber H, Schultz J (eds) Information transfer in normal and abnormal cells. Academic Press, New York, pp 347–358Google Scholar
  11. Blobel G, Dobberstein B (1975) Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol 67:835–851PubMedGoogle Scholar
  12. Blobel G, Sabatini DD (1970) Controlled proteolysis of nascent polypeptides in rat liver cell fractions. J Cell Biol 45:130–145PubMedGoogle Scholar
  13. Bock H, Fleischer S (1975) Preparation of a homogeneous soluble D-β -hydroxybutyrate apodehy-drogenase from mitochondria. J Biol Chem 250:5774–5781PubMedGoogle Scholar
  14. Bonatti S, Blobel G (1979) Absence of cleavable signal sequence in Sindbis virus glycoprotein PE2. J Biol Chem 254:12261–12264PubMedGoogle Scholar
  15. Bonatti S, Cancedda R, Blobel G (1979) Membrane biogenesis, in vitro cleavage, core glycosylation, and integration into microsomal membranes of Sindbis virus glycoproteins. J Cell Biol 80:219–224PubMedGoogle Scholar
  16. Bosch FX, Orlich M, Klenk HD, Rott R (1979) The structure of the hemagglutinin a determinant for the pathogenicity of influenza viruses. Virology 95:197–207PubMedGoogle Scholar
  17. Bosch FX, Garten W, Klenk HD, Rott R (1981) Proteolytic cleavage of influenza hemagglutinins: Primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of avian influenza viruses. Virology 113:725–735PubMedGoogle Scholar
  18. Bracha M, Schlesinger MJ (1976) Defects in RNA+ temperature-sensitive mutants of Sindbis virus and evidence for a complex of PE2-E1 viral glycoproteins. Virology 74:441–449PubMedGoogle Scholar
  19. Bracha M, Sagher D, Brown A, Schlesinger MJ (1977a) The protease inhibitor p-nitrophenyl-p-guanidinobenzoate inactivates Sindbis and other enveloped viruses. Virology 77:45–55PubMedGoogle Scholar
  20. Bracha M, Sagher D, Schlesinger MJ (1977b) Reaction of the protease inhibitor p-nitrophenyl-p-guanidinobenzoate with Sindbis virus. Virology 83:246–253PubMedGoogle Scholar
  21. Braun V, Bosch V (1972) Sequence of the murein lipoprotein and the attachment site of the lipid. Eur J Biochem 28:51–69PubMedGoogle Scholar
  22. Braun PE, Radin NS (1969) Interactions of lipids with a membrane structural protein from myelin. Biochemistry 8:4310–4318PubMedGoogle Scholar
  23. Braun V, Renn K (1969) Chemical characterization, spatial distribution and function of a lipoproteinGoogle Scholar
  24. Bretscher MA (1977) Membrane structure: Some general principles. Science 181:622–629Google Scholar
  25. Capone J, Toneguzzo F, Ghosh HP (1982) Synthesis and assembly of membrane glycoproteins: Membrane anchoring COOH-terminal domain of vesicular stomatitis virus envelope glyco-protein G contains fatty acids. J Biol Chem 257:16–19PubMedGoogle Scholar
  26. Chatis PA, Morrison TG (1982) Fatty acid modification of Newcastle disease virus glycoproteins. J Virol 43:342–347PubMedGoogle Scholar
  27. Chattopadhyay PK, Wu HC (1977) Biosynthesis of the covalently linked diglyceride in murein lipoprotein of Escherichia coli. Proc Natl Acad Sci USA 74:5318–5322PubMedGoogle Scholar
  28. Criddle RS, Packer L, Shich P (1977) Oligomycin-dependent ionophoric protein subunit of mito-chondrial adenosine-triphosphatase. Proc Natl Acad Sci USA 74:4806–4810Google Scholar
  29. Cuatrecasas P (1974) Membrane receptors. Annu Rev Biochem 43:169–214PubMedGoogle Scholar
  30. Cuatrecasas P, Hollenberg MD, Chang KJ, Bennett V (1975) Hormone receptor complexes and their modulation of membrane function. Recent Prog Horm Res 31:37–78PubMedGoogle Scholar
  31. Downer NW, Robinson NC, Capaldi RA (1976) Characterization of a seventh different subunit of beef heart cytochrome c oxidase. Similarities between the beef heart enzyme and that from other species. Biochemistry 15:2930–2936PubMedGoogle Scholar
  32. Dunphy WG, Fries E, Urbani LJ, Rothman JE (1981) Early and late functions associated with the Golgi apparatus reside in distinct compartments. Proc Natl Acad Sci USA 78:7453–7457PubMedGoogle Scholar
  33. Engelman DM, Steitz TA (1981) The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis. Cell 23:411–422PubMedGoogle Scholar
  34. Folch J, Ascoli J, Lees M, Meath JA, LeBaron FN (1951) Preparation of lipid extract from brain tissue. J Biol Chem 191:833–841PubMedGoogle Scholar
  35. Folch-Pi J, Lees M (1951) Proteolipids a new type of tissue lipoproteins. Their isolation from brain. J Biol Chem 191:807–817Google Scholar
  36. Folch-Pi J, Sakura JA (1976) Preparation of the proteolipid \apoprotein from bovine heart, liver, and kidney. Biochim Biophys Acta 427:410–427PubMedGoogle Scholar
  37. Folch-Pi J, Stoffyn PJ (1972) Proteolipids from membrane systems. Ann NY Acad Sci 195:86–107PubMedGoogle Scholar
  38. Gagnon J, Finch PR, Wood DD, Moscarello MA (1971) Isolation of a highly purified myelin protein. Biochemistry 10:4756–4763PubMedGoogle Scholar
  39. Garoff H, Schwarz RT (1978) Glycosylation is not necessary for membrane insertion and cleavage of Semliki Forest virus membrane proteins. Nature 274:487–490PubMedGoogle Scholar
  40. Garoff H, Simons K, Dobberstein B (1978) Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro. J Mol Biol 124:587–600PubMedGoogle Scholar
  41. Garten W, Bosch FX, Rott R, Klenk HD (1981) Proteolytic activation of the influenza virus hemagglutinin.The structure of the cleavage site. Virology 115:361–374PubMedGoogle Scholar
  42. Gazotti P, Bock H, Fleischer S (1975) Interaction of D-β -hydroxybutyrate apodehydrogenase with phospholipids. J Biol Chem 250:5782–5790 Gething MJ, Sambrook J (1981) Cell-surface expression of influenza hemagglutinin from a cloned DNA copy of the RNA gene. Nature 293:620–625Google Scholar
  43. Gibson R, Leavitt R, Kornfeld S, Schlesinger S (1978) Synthesis and infectivity of vesicular stomatitis virus containing nonglycosylated G protein. Cell 18:671–679Google Scholar
  44. Gibson R, Schlesinger S, Kornfeld S (1979) The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures. J Biol Chem 254:3500–3607Google Scholar
  45. Gibson R, Kornfeld S, Schlesinger S (1980) A role for oligosaccharides in glycoprotein biosynthesis. Trends Biochem Sci 11:290–293Google Scholar
  46. Gibson R, Kornfeld S, Schlesinger S (1981) The effect of oligosaccharide chains of different sizes on the maturation and physical properties of the G protein of vesicular stomatitis virus. J Biol Chem 256:456–462PubMedGoogle Scholar
  47. Gottschalk A (1966) Glycoproteins -their composition, structure and function. Elsevier, Amsterdam, pp 1–28Google Scholar
  48. Grinna LS, Robbins PW (1979) Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides. J Biol Chem 254:8814–8818PubMedGoogle Scholar
  49. Grinna LS, Robbins PW (1980) Substrate specificities of rat liver microsomal glycosidases which process glycoproteins. J Biol Chem 255:2255–2258PubMedGoogle Scholar
  50. Grover AK, Slotboom AJ, De Haas GH, Hammes GG (1975) Lipid specificity of β-hydroxybuty-rate dehydrogenase activation. J Biol Chem 250:31–38PubMedGoogle Scholar
  51. Hantke K, Braun V (1973) Covalent binding of lipid to protein. Diglyceride and amide-linked fatty acid at the N-terminal end of the murein-lipoprotein of the Escherichia coli outer membrane. Eur J Biochem 34:284–296PubMedGoogle Scholar
  52. Hasilik A (1980) Biosynthesis of lysosomal enzymes. Trends Biochem Sci 5:237–240Google Scholar
  53. Heidmann T, Changeux JP (1978) Structural and functional properties of the acetylcholine receptor protein in its purified and membrane-bound states. Annu Rev Biochem 47:317–357PubMedGoogle Scholar
  54. Hemming FW (1977) Dolichol phosphate, a coenzyme in the glycosylation of animal membrane-bound glycoproteins. Biochem Soc Trans 5:1223–1331PubMedGoogle Scholar
  55. Holzer H, Heinrich PC (1980) Control of proteolysis. Annu Rev Biochem 49:63–91PubMedGoogle Scholar
  56. Huang A, Huang L, Kennel SJ (1980) Monoclonal antibody covalently coupled with fatty acid. J Biol Chem 255:8014–8018Google Scholar
  57. Huang RTC, Rott R, Wahn K, Klenk HD, Kohama T (1980a) The function of neuraminidase in membrane fusion induced by myxoviruses. Virology 107:313–319PubMedGoogle Scholar
  58. Huang RTC, Wahn K, Klenk HD, Rott R (1980b) Fusion between cell membrane and liposomes containing the glycoproteins of influenza virus. Virology 104:294–302PubMedGoogle Scholar
  59. Huang RTC (to be published) Involvement of glycolipids in membrane fusion induced by myxoviruses. J Gen VirolGoogle Scholar
  60. Hubbard SC, IvattRJ (1981) Synthesis and processing of asparagine-linked oligosaccharides. Annu Rev Biochem 50:555–583PubMedGoogle Scholar
  61. Hughes RC (1976) Membrane glycoproteins -a review of structure and function. Butterworths, London, pp 1–60Google Scholar
  62. Hunt LA, Etchison JR, Summers DF (1978) Oligosaccharide chains are trimmed during synthesis of the envelope glycoprotein of vesicular stomatitis virus. Proc Natl Acad Sci USA 75:754–758PubMedGoogle Scholar
  63. Johnson DC, Schlesinger MJ (1980) Vesicular stomatitis and Sindbis virus glycoprotein transport to the cell surface is inhibited by ionophores. Virology 103:407–424PubMedGoogle Scholar
  64. Jokinen M, Gahmberg CG, Andersson LC (1979) Biosynthesis of the major human red cell sialo-glycoprotein, glycophorin A, in a continuous cell line. Nature 279:604–607PubMedGoogle Scholar
  65. Jolles J, Nussbaum JL, Schoentgen F, Mandel P, Jolles P (1977) Structural data concerning the major rat brain myelin proteolipid P7 apoprotein. FEBS Lett 74:190–194PubMedGoogle Scholar
  66. Kääriäinen L, Söderlund H (1978) Structure and replication of alphaviruses. Curr Top Microbiol Immunol 82:15–69PubMedGoogle Scholar
  67. Kaluza G, Rott R, Schwarz RT (1980) Carbohydrate-induced conformational changes of Semliki Forest virus glyeoproteins determine antigenicity. Virology 102:286–299PubMedGoogle Scholar
  68. Karin M, Mintz B (1981) Receptor-mediated endocytosis of transferrin in developmentally toti-potent mouse teratocarcinoma stem cells. J Biol Chem 256:3245–3252PubMedGoogle Scholar
  69. Kathan RH, Winzler RJ (1963) Structure studies on the myxovirus hemagglutination inhibitor of human erythrocytes. J Biol Chem 238:21–25Google Scholar
  70. Keenan TW, Heid HW, Stadler J, Jarasch ED, Franke WW (1982) Tight attachment of fatty acids to proteins associated with milk lipid globular membrane. Eur J Cell Biol 26:270–276PubMedGoogle Scholar
  71. Keil W, Klenk HD, Schwarz RT (1979) Carbohydrates of influenza virus m. Nature of linkage of oligosaccharide side-chains to protein in influenza virus glycoproteins. J Virol 31:253–256PubMedGoogle Scholar
  72. Klemenz R, Diggelmann H (1979) Extracellular cleavage of the glycoprotein precursor of Rous sarcoma virus. J Virol 29:285–292PubMedGoogle Scholar
  73. Klenk HD, Rott R (1980) Cotranslational and posttranslational processing of viral glycoproteins. Curr Top Microbiol Immunol 90:19–47PubMedGoogle Scholar
  74. Klenk HD, Wöllert W, Rott R, Scholtissek C (1974) Association of influenza virus proteins with cytoplasmic fractions. Virology 57:28–41PubMedGoogle Scholar
  75. Klenk HD, Rott R, Orlich M, Blödorn J (1975) Activation of influenza A viruses by trypsin treatment Virology 68:426–439PubMedGoogle Scholar
  76. Klenk HD, Schwarz RT, Schmidt MFG, Wöllert W (1978) The structure and biosynthesis of the carbohydrate moiety of the influenza virus hemagglutinin. Top Infect Dis 3:83–99Google Scholar
  77. Kornfeld R, Kornfeld S (1980) Structure of glycoproteins and their oligosaccharide units. In: Lennarz WJ (ed) The biochemistry of glycoproteins and proteoglycans. Plenum, New York, pp 1–34Google Scholar
  78. Kornfeld S, Li E, Tabas I (1978) The synthesis of complextype oligosaccharides. J Biol Chem 253:7771–7778PubMedGoogle Scholar
  79. Lai JS, Philbrick WM, Wu HC (1980) Acyl moieties in phosholipids are the precursors for the fatty acids in murein lipoprotein of Escherichia coli. J Biol Chem 255:5384–5387PubMedGoogle Scholar
  80. Lai JS, Sarvas M, Brammar WJ, Neugebauer K, Wu HC (1981) Bacillus licheniformis penicillinase synthesized in Escherichia coli contains covalently linked fatty acid and glyceride. Proc Natl Acad Sci USA 78:3506–3510PubMedGoogle Scholar
  81. Lapetina EG, Soto EF, De Robertis E (1968) Lipids and proteolipids in isolated subcellular membranes of rat brain cortex. J Neurochem 15:437–442PubMedGoogle Scholar
  82. Lazarowitz SG, Choppin PW (1975) Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide. Virology 48:440–454Google Scholar
  83. Lees MB, Sakura JD, Sapirstein VS, Curatolo W (1979) Structure and function of proteolipids in myelin and non-myelin membranes. Biochim Biophys Acta 559:209–230PubMedGoogle Scholar
  84. Levinson AD, Courtneidge SA, Bishop JM (1981) Structural and functional domains of the Rous sarcoma virus transforming protein (p60src). Proc Natl Acad Sci USA 78:1624–1628PubMedGoogle Scholar
  85. Lingappa VR, Katz FN, Lodish HF, Blobel G (1978) A signal sequence for the insertion of a trans-membrane glycoprotein. J Biol Chem 253:8667–8670PubMedGoogle Scholar
  86. Lohmeyer J, Klenk HD (1979) A mutant of influenza virus with a temperature-sensitive defect in the posttranslational processing of the hemagglutinin. Virology 93:134–145PubMedGoogle Scholar
  87. Lonberg-Holm K, Philipson L (1981) Virus Receptors, part 2, Chapman and Hall, HampshireGoogle Scholar
  88. MacLennan DH (1975) Resolution of the calcium transport system of sarcoplasmic reticulum. Can J Biochem 53:251–261PubMedGoogle Scholar
  89. MacLennan DH, Yip CC, Iles GH, Seeman P (1972) Isolation of sarcoplasmic reticulum protein. Cold Spring Harbor Symp Quant Biol 37:469–477Google Scholar
  90. Madoff DH, Lenard J (1982) A membrane glycoprotein that accumulates intracellularly: Cellular processing of the large glycoprotein of LaCrosse virus. Cell 28:821–829PubMedGoogle Scholar
  91. Magee AI, Schlesinger MJ (to be published) Fatty acid acylation of eukaryotic cell membrane proteins. Biochim Biophys ActaGoogle Scholar
  92. Marinetti GV, Cattieu K (1982) Tightly (covalently) bound fatty acids in cell membrane proteins. Biochim Biophys Acta 685:109–116PubMedGoogle Scholar
  93. Morré DJ, Kartenbeck J, Franke WW (1979) Membrane flow and interconversions among endo-membranes. Biochim Biophys Acta 559:71–152PubMedGoogle Scholar
  94. Morgan EH (1981) Inhibition of reticulocyte iron uptake by NH4Cl and CH3HN2. Biochim Biophys Acta 642:119–134PubMedGoogle Scholar
  95. Moscarello MA, Gagnon J, Wood DD, Anthony J, Epand RM (1973) Conformational flexibility of a myelin protein. Biochemistry 12:3402–3406PubMedGoogle Scholar
  96. Mowa NR, Nakamura K, Inouye M (1980) Amino acid sequence of the signal peptide of omp A protein, a major outer membrane protein of Escherichia coli. J Biol Chem 255:27–29Google Scholar
  97. Murakami M, Sekine H, Funahashi S (1962) Proteolipid from beef heart muscle. Application of organic dialysis to preparation of proteolipid. J Biochem (Tokyo) 51:431–435 Nagai Y, Klenk HD, Rott R (1976) Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus. Virology 72:494–508Google Scholar
  98. Nakamura K, Compans RW (1978) Effects of glucosamine, 2-deoxy-D-glucose, and tunicamycin on glycosylation, sulfation, and assembly of influenza virus glycoproteins. Virology 84:303–319PubMedGoogle Scholar
  99. Nakamura K, Bhown AS, Compans RW (1980) Glycosylation sites on influenza viral glycoproteins. Virology 107:208–221PubMedGoogle Scholar
  100. Nelson CE, Ryan CA (1980) In vitro synthesis of preproteins of vacuolar compartmented proteinase inhibitors that accumulate in leaves of wounded tomato plants. Proc Natl Acad Sci USA 77:1975–1979PubMedGoogle Scholar
  101. Nelson N, Eytan E, Notsani B, Sigrist H, Sigrist-Nelson K, Gitler C (1977) Isolation of chloroplast N,N-dicyclo-hexylcarbodiimide-binding proteolipid, active in proton translocatioa Proc Natl Acad Sci USA 74:2375–2378PubMedGoogle Scholar
  102. Nielsen JBK, Lampen JO (1982) Membrane-bound penicillinases in gram-positive bacteria. J Biol Chem 257:4490–4495PubMedGoogle Scholar
  103. Nielsen JBK, Caulfield MP, Lampen JO (1981) Lipoprotein nature of bacillus licheniformis membrane penicillinase. Proc Natl Acad Sci USA 78:3511–3515PubMedGoogle Scholar
  104. Niemann H, Klenk HD (1981) Coronavirus glycoprotein El: A new type of viral glycoprotein. J Mol Biol 153:993–1010PubMedGoogle Scholar
  105. Octave JN, Schneider YJ, Crichton RR, Trouet A (1981) Transferrin uptake by cultured rat embryo fibroblasts. The influence of temperature and incubation time, subcellular distribution, and short-term kinetic studies. Eur J Biochem 115:611–618PubMedGoogle Scholar
  106. Omary MB, Trowbridge IS (1981a) Biosynthesis of the human transferrin receptor in culture cells. J Biol Chem 256:12888–12892PubMedGoogle Scholar
  107. Omary MB, Trowbridge IS (1981b) Covalent binding of fatty acid to the transferrin receptor in cultured cells. J Biol Chem 256:4715–4718PubMedGoogle Scholar
  108. Omura S (1976) The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacterial Rev 40:681–697Google Scholar
  109. Palade G (1975) Intracellular aspects of the process of protein synthesis. Science 189:347–358PubMedGoogle Scholar
  110. Parodi AJ, Leloir LF (1979) The role of lipid intermediated in the glycosylation of proteins in the eucaryotic cell. Biochim Biophys Acta 559:1–37PubMedGoogle Scholar
  111. Petri WA JR, Wagner RR (1980) Glycoprotein micelles isolated from vesicular stomatitis virus spontaneously partition into sonicated phosphatidylcholine vesicles. Virology 107:543–547PubMedGoogle Scholar
  112. Petri WA JR, Pal A, Barenholz Y, Wagner RR (1981) Fluorescence anisotropy of a fatty acid covalently linked in vivo to the glycoprotein of vesicular stomatitis virus. J Biol Chem 256: 2625–2627PubMedGoogle Scholar
  113. Porter AG, Barker C, Carvey NH, Hallewell RA, Threlfall G, Emtage JS (1979) Complete nucleotide sequence of an influenza virus hemagglutinin gene from cloned DNA. Nature 282:471–477PubMedGoogle Scholar
  114. Reich E, Rifkin DB, Shaw E (eds) (1975) Protease and biological control. Cold Spring Harbor Laboratory, New YorkGoogle Scholar
  115. Rice CM, Bell JR, Hunkapillar MW, Strauss EG, Strauss JH (1982) Isolation and characterization of the hydrophobic COOH-terminal domains of the Sindbis virion glycoproteins. J Mol Biol 154:355–378PubMedGoogle Scholar
  116. Robbins PW, Hubbard SC, Turco SJ, Wirth DF (1977) Proposal for a common oligosaccharide intermediate in the synthesis of membrane glycoproteins. Cell 12:893–900PubMedGoogle Scholar
  117. Robertson JS, Etchison JR, Summers DF (1976) Glycosylation sites of vesicular stomatitis virus glycoprotein. J Virol 19:871–878PubMedGoogle Scholar
  118. Robinson NC, Capaldi RA (1977) Interaction of detergents with cytochrome oxidase. Biochemistry 16:375–380PubMedGoogle Scholar
  119. Rogers J, Early P, Carter C, Calame K, Bond M, Hood L, Wall R (1980) Two mRNAs with different 3 ends encode membrane-bound and secreted forms of immunoglobulin µ chain. Cell 20:303–312PubMedGoogle Scholar
  120. Rose JK, Gallione CJ (1981) Nucleotide sequences of the mRNAs encoding the vesicular stomatitis virus G and M proteins determined from cDNA clones containing the complete coding regions. J Virol 39:519–528PubMedGoogle Scholar
  121. Rothman JE (1981) The Golgi apparatus: Two organelles in tandem. Science 213:1212–1219PubMedGoogle Scholar
  122. Rothman JE, Lodish HF (1977) Synchronised transmembrane insertion and glycosylation of a nascent membrane protein. Nature 269:775–780PubMedGoogle Scholar
  123. Rott R (1977) The structural basis of the function of influenza virus glycoproteins. Med Microbiol Immunol 164:23–33PubMedGoogle Scholar
  124. Rott R (1979) Molecular basis of infectivity and pathogenicity of myxoviruses. Arch Virol 59: 285–298PubMedGoogle Scholar
  125. Sabatini DD, Kreibich G, Morimoto T, Adesnik M (1982) Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol 92:1–22PubMedGoogle Scholar
  126. Sands JA, Reinhardt A, Auperin D, Landin P (1979) Inhibition of entry of the Upid-containing bacteriophage PR 4 by fatty acid derivatives. J Virol 29:413–416PubMedGoogle Scholar
  127. Sawai T, Lampen JO (1974) Purification and characteristics of plasma membrane penicillinase from Bacillus licheniformis 749/C. J Biol Chem 249:6288–6294PubMedGoogle Scholar
  128. Scheid A, Choppin PW (1974) Identification and biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity by proteolytic cleavage of an intact precursor protein of Sendai virus. Virology 57:475–490PubMedGoogle Scholar
  129. Scheid A, Choppin PW (1976) Protease activation mutants of Sendai virus. Activation of biological properties by specific proteases. Virology 69:265–277PubMedGoogle Scholar
  130. Schlesinger MJ (1981) Proteolipids. Annu Rev Biochem 50:193–206PubMedGoogle Scholar
  131. Schlesinger MJ, Kääriäinen L (1980) Translation and processing of alphavirus proteins. In: Schlesinger WR (ed) Togaviruses. Academic Press, New York, pp 371–392Google Scholar
  132. Schlesinger MJ, Malfer C (1982) Blocking fatty acid acylation of glycoproteins inhibits vesicular stomatitis and Sindbis virus particle formation. J Biol Chem 257:9887–9890PubMedGoogle Scholar
  133. Schlesinger S, Schlesinger MJ (1972) Formation of Sindbis virus proteins: Identification of a precursor for one of the envelope proteins. J Virol 10:925–932PubMedGoogle Scholar
  134. Schlesinger MJ, Magee AI, Schmidt MFG (1980) Fatty acid acylation of proteins in cultured cells. J Biol Chem 255:10021–10024PubMedGoogle Scholar
  135. Schlesinger MJ, Magee AI, Schmidt MFG (1981) Fatty acid acylation of VSV glycoprotein. In: Bishop DHL, Compans RW (eds) The replication of negative strand viruses. Elsevier North-Holland, Amsterdam, pp 673–678Google Scholar
  136. Schmidt MFG (1982a) Acylation of proteins -a new type of modification of membrane glycoproteins. Trends Biochem Sci 7:322–324Google Scholar
  137. Schmidt MFG (1982b) Acylation of viral spike glycoproteins -A feature of enveloped RNA-viruses. Virology 116:327–338PubMedGoogle Scholar
  138. Schmidt MFG (1982c) Preparation of viral envelope components. In: Kornberg HL, Metcalf J, Hesketh TR, Northcote DL, Pogson C, Tipton KF (eds) Techniques in lipid and membrane biochemistry. Elsevier North-Holland, Amsterdam vol B419, pp 1–15Google Scholar
  139. Schmidt MFG, Schlesinger MJ (1979) Fatty acid binding to vesicular stomatitis virus glycoprotein -a new type of posttranslational modification of the viral glycoprotein. Cell 17:813–819PubMedGoogle Scholar
  140. Schmidt MFG, Schlesinger MJ (1980) Relation of fatty acid attachment to the translation and maturation of vesicular stomatitis and Sindbis virus membrane glycoproteins. J Biol Chem 255:3334–3339PubMedGoogle Scholar
  141. Schmidt MFG, Bracha M, Schlesinger MJ (1979) Evidence for covalent attachment of fatty acids to Sindbis virus glycoproteins. Proc Natl Acad Sci USA 76:1678–1691Google Scholar
  142. Scholtissek C, Bowles AL (1975) Isolation and characterization of temperature-sensitive mutants of fowl plague virus. Virology 67:567–587Google Scholar
  143. Schwarz RT, Datema R (1982) The lipid pathway of protein glycosylation, its inhibitors, and the biological significance of protein-bound carbohydrates. Adv Carbohyd Chem Biochem 40: 287–379Google Scholar
  144. Schwarz RT, Schmidt MFG (1982) Tunicamycin in virology. In: Tamura G (ed) Tunicamycin. Japan Scientific Societies, Tokyo, pp 99–116Google Scholar
  145. Schwarz RT, Rohrschneider JM, Schmidt MFG (1976) Suppression of glycoprotein formation of Semliki Forest, influenza, and avian sarcoma virus by tunicamycin. J Virol 19:782–791PubMedGoogle Scholar
  146. Schwarz RT, Schmidt MFG, Lehle L (1978) Glycosylation in vitro of Semliki Forest virus and influenza virus glycoproteins and its suppression by nucleotide-2-deoxyhexose. Eur J Biochem 85:163–172PubMedGoogle Scholar
  147. Sebald W, Graf T, Lukins AB (1979) The dicyclohexylcarbodiimide-binding protein of the mito-chondrial ATPase complex from Neurospora crassa and Saccharomyces cerevisiae. Eur J Biochem 93:587–599PubMedGoogle Scholar
  148. Shapiro SZ, August JA (1976) Proteolytic cleavage events in oncomavirus protein synthesis. Biochim Biophys Acta 458:375–396PubMedGoogle Scholar
  149. Simons K, Garoff H (1980) The budding mechanism of enveloped animal viruses. J Gen Virol 50:1–21PubMedGoogle Scholar
  150. Simons K, Sarvas M, Garoff H, Helenius A (1978) Membrane-bound and secreted forms of peni-cillinase from Bacillus licheniformis. J Mol Biol 126:673–690PubMedGoogle Scholar
  151. Singer SJ, Nicolson GL (1975) The fluid mosaic model of the structure of cell membranes. Science 175:720–731Google Scholar
  152. Smith JF, Brown DT (1977) Envelopment of Sindbis virus: Synthesis and organization of proteins in cells infected with wild type and maturation defective mutants. J Virol 22:662–678PubMedGoogle Scholar
  153. Smith WP, Tai PC, Davis BD (1981) Bacillus licheniformis penicillinase: Cleavage and attachment of lipid during cotranslational secretion. Proc Natl Acad Sci USA 78:3501–3505PubMedGoogle Scholar
  154. Spector AA (1975) Fatty acid binding to plasma albumin. J Lip Res 16:165–179Google Scholar
  155. Stoffyn P, Folch-Pi J (1971) On the type of linkage binding fatty acids present in brain white matter proteolipid apoprotein. Biochem Biophys Res Commun 44:157–161PubMedGoogle Scholar
  156. Sturman LS, Holmes KV, Behnke J (1980) Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid. J Virol 33:449–462PubMedGoogle Scholar
  157. Suchanek G, Kreil G, Hermodson MA (1980) Amino acid sequence of honeybee prepromellitin synthesized in vitro. Proc Natl Acad Sci USA 75:701–704Google Scholar
  158. Tabas I, Kornfeld S (1979) Purification and characterization of rat liver Golgi-mannosidase capable of processing asparagine-linked oligosaccharides. J Biol Chem 254:11655–11663PubMedGoogle Scholar
  159. Tabas I, Schlesinger S, Kornfeld S (1978) The processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis G protein and the IgG-heavy chain. J Biol Chem 253:716–722PubMedGoogle Scholar
  160. Tartakoff AM (1980) The Golgi complex: crossroads for vesicular traffic. Int Rev Exp Pathol 22:227–252PubMedGoogle Scholar
  161. Tzagoloff A, Meagher P (1972) Assembly of the mitochondrial membrane system. J Biol Chem 247:594–603PubMedGoogle Scholar
  162. Vik SB, Capaldi RA (1977) Lipid requirements for cytoehrome c oxidase activity. Biochemistry 16:5755–5759PubMedGoogle Scholar
  163. Waechter CJ, Lennarz WJ (1976) The role of polyprenol-linked sugars in glycoprotein synthesis. Annu Rev Biochem 45:95–112PubMedGoogle Scholar
  164. Ward CW (1981) Structure of influenza virus hemagglutinin. Curr Top Microbiol Immunol 94:1–71PubMedGoogle Scholar
  165. Ward CW, Dopheide TAA (1979) Primary structure of the Hongkong (H3) hemagglutinin. Br Med Bull 35:51–56PubMedGoogle Scholar
  166. Wickner W (1979) The assembly of proteins into biological membranes: The membrane trigger hypothesis. Annu Rev Biochem 48:23–45PubMedGoogle Scholar
  167. Wilson IA, Skehel JJ, Wiley DC (1981) Structure of the hemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature 289:366–373PubMedGoogle Scholar
  168. Wirth DF, Katz F, Small B, Lodish HF (1977) How a single-stranded Sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins. Cell 10:253–263PubMedGoogle Scholar
  169. Wold F (1981) In vivo chemical modification of proteins (posttranslational modification). Annu Rev Biochem 50:783–814PubMedGoogle Scholar
  170. Yamamoto S, Lampen JO (1975) Membrane penicillinase of Bacillus licheniformis 749/C, a phos-pholipoprotein. J Biol Chem 250:3212–3213PubMedGoogle Scholar
  171. Yamamoto S, Lampen JO (1976a) Membrane penicillinase of Bacillus licheniformis 749/C: Sequence and possible repeated tetrapeptide structure of the phospholipopeptide region. J Biol Chem 251:1457–1461Google Scholar
  172. Yamamoto S, Lampen JO (1976b) The hydrophobic membrane penicillinase of Bacillus licheni formis 749/C. J Biol Chem 251:4102–4110PubMedGoogle Scholar
  173. Zilberstein A, Snider MD, Porter M, Lodish HF (1980) Mutants of vesicular stomatitis virus blocked at different stages in maturation of the viral glycoprotein. Cell 21:417–427PubMedGoogle Scholar
  174. Zill LP, Harmon EA (1962) Chloroplast proteolipid. Biochim Biophys Acta 53:579–581Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Michael F. G. Schmidt
    • 1
  1. 1.Institut für VirologieJustus-Liebig-Universität GiessenGiessenFederal Republic of West-Germany

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