Intubating Conditions with Org NC 45: A Comparison with Suxamethonium and Pancuronium

  • R. S. J. Clarke
  • R. K. Mirakhur
  • I. M. Bali
  • J. W. Dundee
Chapter
Part of the European Academy of Anaesthesiology book series (ANAESTHESIOLOGY, volume 2)

Abstract

Org NC 45 is a neuromuscular blocking agent structurally related to pancuronium but without any significant cardiovascular side effects(1). Both animal and human studies have shown it to be short acting, less cumulative than pancuronium and easily antagonised by neostigmine(2, 3, 4).

Keywords

Neuromuscular Blocking Neuromuscular Blocking Agent Neuromuscular Blocking Drug Tracheal Intu Satisfactory Grade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Marshall RJ, McGrath JC, Miller RD, Docherty JR and Lamar JC (1980) Comparison of the cardiovascular actions of Org NC 45 with those produced by other non-depolarizing neuromuscular blocking agents in experimental animals. Br J Anaesth 52; 21A.Google Scholar
  2. 2.
    Agoston S, Salt P, Newton D, Bencini A, Boomsma P and Erdmann W (1980) The neuromuscular blocking action of Org NC 45, a new pancuronium derivative, in anaesthetised patients. A pilot study. Br J Anaesth 52; 53S.PubMedCrossRefGoogle Scholar
  3. 3.
    Crul JF and Booij LHDJ (1980) First clinical experiences with Org NC 45. Br J Anaesth 52; 49S.PubMedCrossRefGoogle Scholar
  4. 4.
    Marshall IG, Agoston S. Booij LHDJ, Durant NN and Foldes FF (1980) Pharmacology of Org NC 45 compared with other non-depolarizing neuromuscular blocking drugs. Br J Anaesth 52; 11S.PubMedCrossRefGoogle Scholar
  5. 5.
    Lund I and Stovner J (1962) Experimental and clinical experiences with a new muscle relaxant Ro 4–3816, diallyl-nor-toxiferine. Acta Anaesth Scand 6; 85.PubMedCrossRefGoogle Scholar
  6. 6.
    Young HSA, Clarke RSJ and Dundee JW (1975) Intubating conditions with AH 8165 and suxamethonium. Anaesthesia 30; 30.PubMedCrossRefGoogle Scholar
  7. 7.
    Viby-Mogensen J, Jørgensen BC, Engbaek J and Sørensen B (1980) On Org NC 45 and halothane anaesthesia: preliminary results. Br J Anaesth 52; 67S.PubMedCrossRefGoogle Scholar
  8. 8.
    Fahey MR, Morris RB, Miller RD, Sohn YJ, Cronnelly R and Gencarelli P (1981) Clinical pharmacology of Org NC 45 (Norcuron): a new non-depolarising muscle relaxant. Anesthesiology 55; 6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • R. S. J. Clarke
  • R. K. Mirakhur
  • I. M. Bali
  • J. W. Dundee

There are no affiliations available

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