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The Obese Strain (OS) of Chickens With Spontaneous Autoimmune Thyroiditis: Review of Recent Data

  • G. Wick
  • R. Boyd
  • K. Hala
  • L. De Carvalho
  • R. Kofler
  • P. U. Müller
  • R. K. Cole
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 91)

Abstract

The Obese strain (OS) of chickens was developed about 15 years ago by selective breeding for the phenotypic trait of hypothyroidism [1, 2]. The fact that the clinical symptoms are attributable to a spontaneously arising thyroiditis which is autoimmune in nature was first recognized 5 years later [3]. In subsequent years this avian model was established as the closest counterpart to human Hashimoto’s disease [4]; the data accumulated by 1974 have already been presented in a comprehensive review [5].

Keywords

Autoimmune Thyroiditis Rous Sarcoma Virus Suppressor Mechanism Thyroid Epithelial Cell Normal Chicken 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Glossary of Abbreviations

ADCC

antibody-dependent cellular cytotoxicity

BSA

bovine serum albumin

CS

Cornell C strain

DCC

direct cellular cytotoxicity

EAE

experimental allergic encephalomyelitis

EAT

experimentally induced autoimmune thyroiditis

FITC

fluorescein isothiocyanate

MCA

microcytotoxicity assay

MHC

major histocompatibility complex

NWL

normal White Leghorn

OS

Obese strain

PHA

phytohemagglutinin

RBC

red blood cells

RFC

rosette-forming cells

RSV

Rous sarcoma virus

SAT

spontaneous autoimmune thyroiditis

SCC

spontaneous cellular cytotoxicity

TA-CRBC

tannic acid only treated chicken red blood cells

Tg

thyroglobulin

Tg-CRBC

chicken red blood cells coated with thyroglobulin

TRITC

tetramethylrhodamine-isothiocyanate

TSH

thyroid stimulating hormone

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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • G. Wick
    • 1
  • R. Boyd
    • 1
  • K. Hala
    • 1
  • L. De Carvalho
    • 2
  • R. Kofler
    • 1
  • P. U. Müller
    • 1
  • R. K. Cole
    • 3
  1. 1.Institute for General and Experimental PathologyUniversity of InnsbruckAustria
  2. 2.Department of ImmunologyMiddlesex Hospital, Medical SchollLondonUK
  3. 3.Department of Poultry ScienceCornell UniversityIthacaUSA

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