Modern Trends in Human Leukemia IV pp 452-454 | Cite as
Studies of the Association of Leukemogenic and Oncogenic Properties in Avian Leukemia Viruses
Abstract
The transmission of avian leukosis virus (ALV) in chickens doesn’t cause only leukosis, but also nonleucocytic neoplasias (Carr 1960; Graf and Berg 1978; Löliger 1964). After inoculation with avian myeloblastosis virus (AMV), kidney tumors (nephroblastomas) and Osteopetrosis or osteosarcomas distinctly different to leukemia may develope in the infected, susceptible chickens. The nephroblastomas, which might be compared with the Wilm’s tumor in man, are mostly consisting of different neoplastic cellformations, such as cystoma, adenoma, endothelioma, hemangioma and fibrocytic neoplasias. It is not known that other avian tumor viruses, which don’t belong to the ALV group, such as the Marek’s disease herpes virus (MDHV), reveal a similar tumor spectrum.
Keywords
Aplastic Anemia Kidney Tumor Oncogenic Property Avian Myeloblastosis Virus Avian Leukosis VirusPreview
Unable to display preview. Download preview PDF.
References
- Carr JG (1960) Kidney carcinomas of the fowl induced by the MH2 reticulo-endothelioma virus. Br J Cancer 14:77–82PubMedCrossRefGoogle Scholar
- Graf T, Beug H (1978) Avian leukemia viruses; interaction with their target cells in vivo and in vitro. Biochem Biophys Acta 516:269–299PubMedGoogle Scholar
- Löliger HC (1964) Atypische Veränderungen in den Nieren von Hühnern nach experimenteller Infektion mit einem übertragbaren Leukosestamm. Dt Tierärztl. Wschr 68:517–521Google Scholar
- Ogura H, Gelderblom H, Bauer H (1974) Isolation of avian nephroblastoma virus from avian myeloblastosis virus by the infectious DNA technique. Intervirology 4:69–76PubMedCrossRefGoogle Scholar
- Smith RE, Moscovici C (1969) The oncogenic effects of nontransforming viruses from avian Myeloblastosis virus. Cancer Res 29:1356–1366PubMedGoogle Scholar