PRCII, a Representative of a New Class of Avian Sarcoma Viruses

  • P. K. Vogt
  • J. C. Neil
  • C. Moscovici
  • M. L. Breitman
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 26)

Abstract

The Poultry Research Center Virus II (PRC II) is a replication-defective avian sarcoma virus with envelope determinants of the A and B subgroups. In nonproducing cells transformed by PRCII the products of the replicative genes gag, pol, and env are not demonstrable, but a single polyprotein of Mr 105,000 (p105) can be detected. P105 contains peptides of the gag proteins p19 and p27 plus transformationspecific sequences. It does not contain peptides of gPr95env of Pr180gag-PoI (with the possible exception of one pol peptide). The transformation-specific sequences of p105 are distinct form those of p100 of avian carcinoma virus MH2, of p1 10 coded for by avian myelocytoma virus MC29, and of p75 or p40 of avian erythroblastosis virus AEV. They also show no resemblance to p60src of Rous sarcoma virus. P105 is phosphorylated on a tyrosine residue and has an associated Phosphokinase activity. P105 appears to be capable of autophosphorylation and of phosphorylating homologous immunoglobulin.

Keywords

Rous Sarcoma Virus Helper Virus Avian Leukosis Virus Avian Sarcoma Virus Cetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Barbacid M, Beemon K, Devare SG (1980) Proc Natl Acad Sci USA 77:5158–5162PubMedCrossRefGoogle Scholar
  2. Barbacid M, Lauver AV, Devare SG (1980) J Virol 33:196–207PubMedGoogle Scholar
  3. Barbacid M, Breitmann ML, Lauver AV, Long LK, Vogt PK (1981) Virology 110:411–419PubMedCrossRefGoogle Scholar
  4. Bister K, Hayman MJ, Vogt PK (1977) Virology 82:431–448PubMedCrossRefGoogle Scholar
  5. Bister K, Vogt PK (1978) Virology 88:213–221PubMedCrossRefGoogle Scholar
  6. Breitman ML, Neil JC, Moscovici C, Vogt PK (1981) Virology 108:1–12PubMedCrossRefGoogle Scholar
  7. Brugge JS, Erikson RL (1977) Nature 269:346–348PubMedCrossRefGoogle Scholar
  8. Carr JG, Campbell JG (1958) Brit J Cancer 12:631–635PubMedCrossRefGoogle Scholar
  9. Collett MS, Erikson RL (1978) Proc Natl Acad Sci USA 75: 2021–2024PubMedCrossRefGoogle Scholar
  10. Duesberg PH, Vogt PK (1970) Proc Natl Acad Sci USA 67:1673–1680PubMedCrossRefGoogle Scholar
  11. Duff R, Vogt PK (1969) Virology 39:18–30PubMedCrossRefGoogle Scholar
  12. Graf T (1975) Z Naturforsch 30:847–849Google Scholar
  13. Hanafusa T, Wang L-H, Anderson SM, Karess RE, Hayward W, Hanafusa H (1980) Proc Natl Acad Sci USA 77:3009–3013PubMedCrossRefGoogle Scholar
  14. Hu SSF, Moscovici C, Vogt PK (1978) Virology 89:162–178PubMedCrossRefGoogle Scholar
  15. Hu SSF, Vogt PK (1979) Virology 92:278–284PubMedCrossRefGoogle Scholar
  16. Ishizaki R, Shimizu T (1970) Cancer Res 30:2827–2831PubMedGoogle Scholar
  17. Hunter T, Sefton BM (1980) Proc Natl Acad Sci USA 77:1311–1315PubMedCrossRefGoogle Scholar
  18. Kawai S, Yoshida M, Segawa K, Sugiyama H, Ishizaki R, Toyoshima K (1980) Proc Natl Acad Sci USA 77:6199–6203PubMedCrossRefGoogle Scholar
  19. Lai MMC, Hu SSF, Vogt PK (1979) Virology 97:366–377PubMedCrossRefGoogle Scholar
  20. Lee WH, Bister K, Pawson A, Robins T, Moscovici C, Duesberg PH (1980) Proc Natl Acad Sci USA 77:2018–2022PubMedCrossRefGoogle Scholar
  21. Levinson AD, Oppermann H, Levintow L, Varmus HE, Bishop JM (1978) Cell 15:561–572PubMedCrossRefGoogle Scholar
  22. Manteuil-Brutlag S, Liu SI, Kaplan HS (1980) Cell 19:643–652PubMedCrossRefGoogle Scholar
  23. Neil JC, Breitman ML, Vogt PK (1981) Virology 108:98–110PubMedCrossRefGoogle Scholar
  24. Payne LN, Biggs PM (1966) Virology 29:190–198PubMedCrossRefGoogle Scholar
  25. Roussel M, Saule S, Lagrou C, Rommens C, Beug H, Graf T, Stehelin D (1979) Nature 281:452–455PubMedCrossRefGoogle Scholar
  26. Shealy DJ, Mosser AG, Rueckert RR (1980) J Virol 34:431–437PubMedGoogle Scholar
  27. Sheiness D, Bishop JM (1979) J Virol 31:514–521PubMedGoogle Scholar
  28. Sheiness D, Bister K, Moscovici C, Fanshier L, Gonda T, Bishop JM (1980) J Virol 33:962–968PubMedGoogle Scholar
  29. Sherr CJ, Fedele LA, Oskarsson M, Maizel J, Vande Woude G (1980) J Virol 34:200–212PubMedGoogle Scholar
  30. Shibuya M, Hanafusa T, Hanafusa H, Stephenson JR (1980) 77:6536–6540Google Scholar
  31. Spector D, Varmus HE, Bishop JM (1978) Proc Natl Acad Sci USA 75:4102–4106PubMedCrossRefGoogle Scholar
  32. Stehelin D, Varmus HE, Bishop JM, Vogt PK (1976) Nature 260:170–173PubMedCrossRefGoogle Scholar
  33. Van de Ven WJM, Khan AS, Reynolds FH jr, Mason KT, Stephenson JR (1980) J Virol 33:1034–1045PubMedGoogle Scholar
  34. Wang L-H, Duesberg PH, Beemon K, Vogt PK (1975) J Virol 16:1051–1070PubMedGoogle Scholar
  35. Witte ON, Rosenberg N, Paskind M, Shields A, Baltimore D (1978) Proc Natl Acad Sci USA 75:2488–2492PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • P. K. Vogt
  • J. C. Neil
  • C. Moscovici
  • M. L. Breitman

There are no affiliations available

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