Biochemical Effects of Gerontopsychopharmacological Agents

  • S. Hoyer
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 55 / 2)

Abstract

Discussion of the biochemical effectiveness of gerontopsychopharmacological agents in gerontopsychiatric (i.e. demented) patients should be based on criteria concerning cerebral blood flow, cerebral oxygen consumption and cerebral glucose uptake as biologically important brain parameters which might be predominantly altered in dementia. Physiologically, a close relationship exists between cerebral blood flow on the one hand and the cerebral metabolic rates of oxygen and glucose on the other (Alberti et al., 1975; Alexander et al., 1965, 1968; Cohen et al., 1964,1968; Folbergrova et al., 1972; Gottstein et al., 1977, 1976; Granholm et al., 1969; Granholm and Siesjö, 1969, 1971; Hamer et al., 1976, 1978; Hoyer et al., 1974; Kaasik et al., 1970; Kogure et al., 1970; Siesjö and Messeter, 1971; Siesjö et al., 1971; Siesjö and Zwetnow, 1970; Zwetnow, 1970). Therefore these parameters should not be considered separately in dementia. Cerebral blood flow variations should also be discussed in dementia although the disturbances of the metabolic brain parameters might be of greater importance in this disease (see below).

Keywords

Cerebral Blood Flow Regional Cerebral Blood Flow Dementia Patient Senile Dementia Cerebral Metabolic Rate 
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  • S. Hoyer

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